930597-95-8Relevant academic research and scientific papers
CANNABINOID DERIVATIVES AND PRECURSORS, AND ASYMMETRIC SYNTHESIS FOR SAME
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, (2021/03/19)
The present disclosure relates to new cannabinoid derivatives and precursors and catalytic asymmetric processes for their preparation. The disclosure also relates to pharmaceutical compositions and pharmaceutical and analytical uses of the new cannabinoid derivatives. For instance, the disclosure relates to the preparation of new precursors, and the use of such precursor compounds for the preparation of isotope labelled cannabinoid products using chiral and achiral catalysts and catalytic processes. The deuterium, carbon-13 and carbon-14 containing compounds can be prepared and purified prior to transformation to the desired individual deuterated cannabinoid products.
SYNTHESIS OF CANNABINOIDS
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Paragraph 0157; 0158, (2019/02/05)
Provided are synthesis processes and intermediates for preparing cannabinoids and analogs.
Enantioselective Total Synthesis of Cannabinoids - A Route for Analogue Development
Shultz, Zachary P.,Lawrence, Grant A.,Jacobson, Jeffrey M.,Cruz, Emmanuel J.,Leahy, James W.
supporting information, p. 381 - 384 (2018/01/27)
A practical synthetic approach to Δ9-tetrahydrocannabinol (1) and cannabidiol (2) that provides scalable access to these natural products and should enable the generation of novel synthetic analogues is reported.
Stereodivergent total synthesis of Δ9-tetrahydrocannabinols
Schafroth, Michael A.,Zuccarello, Giuseppe,Krautwald, Simon,Sarlah, David,Carreira, Erick M.
supporting information, p. 13898 - 13901 (2015/02/18)
All four stereoisomers of Δ9-tetrahydrocannabinol (Δ9-THC) were synthesized in concise fashion using stereodivergent dual catalysis. Thus, following identical synthetic sequences and applying identical reaction conditions to the same
Synthesis of (-)-Δ9-trans-tetrahydrocannabinol: Stereocontrol via mo-catalyzed asymmetric allylic alkylation reaction
Trost, Barry M.,Dogra, Kalindi
, p. 861 - 863 (2007/10/03)
(Chemical Equation Presented) Δ9-THC is synthesized in enantiomericaly pure form, where all of the stereochemistry is derived from the molybdenum-catalyzed asymmetric alkylation reaction of the extremely sterically congested bis-ortho-substitut
