93065-70-4Relevant academic research and scientific papers
Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits
Ulven, Trond,Receveur, Jean-Marie,Grimstrup, Marie,Rist, ?ystein,Frimurer, Thomas M.,Gerlach, Lars-Ole,Mathiesen, Jesper Mosolff,Kostenis, Evi,Uller, Lena,H?gberg, Thomas
, p. 6638 - 6641 (2007/10/03)
Hits from an in silico derived focused library for CRTH2 were transformed into highly selective antagonists with favorable ADME properties. Oral administration of 4-bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxyacetic acid (19) inhibited peribronchial e
Heterocyclic Systems: Part II - Synthesis and Antifeedant Activity of 3-(1-Phenyl-1H-pyrazol-4-yl)benzofuran-2-carboxylic Acids
Reddy, G. Jagath,Sbitha, G.,Rao, A. V. Subba
, p. 99 - 100 (2007/10/02)
3-(1-Phenyl-1H-pyrazol-4-yl)benzofuran-2-carboxylic acids (IVa-e) have been synthesised from 1-phenyl-4-(2-hydroxybenzoyl)pyrazoles (IIa-e) via their O-alkylated products (IIIa-e).The compounds IIa-e in turn have been prepared starting from the correspond
