93069-40-0

Upstream product

• 93069-39-7 5-phenylsulfinylspiro<2.4>heptan-4-one 
• 5771-32-4 spiro[2.4]heptan-4-one 
• 670-98-4 methyl benzenesulfinate 

Downstream Products

• 118467-15-5 5-Butyl-5-phenylsulfanyl-spiro[2.4]hept-6-en-4-one 
• 118467-13-3 5-Methyl-5-phenylsulfanyl-spiro[2.4]hept-6-en-4-one 

Relevant academic research and scientific papers

Synthons for Syntheses of Spiroheptane Analogues of Prostaglandins

Methods for the preparation of synthons for syntheses of spiroheptane analogues of prostaglandins are described.Two of them (1a and 1b) enable the syntheses of 11-deoxy-type compounds and were prepared from spiroheptan-4-one (3) which after transformation into the 5-phenylthio-α, β-unsaturated ketone 5 was subjected to conjugate addition of organocuprate reagent 6.The third synthon (2) - a potential intermediate in syntheses of complete spiroheptane analogues of prostaglandins-was prepared from the bicyclic ketone 10 by Baeyer-Villiger oxidation follo wed by epoxidation. - Keywords: Prostaglandin analogues; Spiroheptan-4-ones; 2H-Cyclopentafuran-2-ones; Desulfurization; Conjugate addition of cuprate