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670-98-4

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670-98-4 Usage

Description

METHYL BENZENESULFINATE is an organic compound that serves as a reagent in the synthesis of various chemical compounds, particularly sulfinyl compounds and symmetrical disulfides. It is known for its ability to facilitate the formation of these compounds, making it a valuable component in chemical reactions.

Uses

Used in Chemical Synthesis:
METHYL BENZENESULFINATE is used as a reagent for the synthesis of sulfinyl compounds, which are important intermediates in the production of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its presence in the reaction helps to form the desired sulfinyl compounds efficiently.
Used in Symmetric Disulfide Synthesis:
METHYL BENZENESULFINATE is also used in the synthesis of symmetrical disulfides, which are compounds containing two identical thiol groups connected by a disulfide bond. These symmetrical disulfides have applications in various industries, including the production of rubber, dyes, and pharmaceuticals.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 5, p. 723, 1973Tetrahedron Letters, 13, p. 5313, 1972 DOI: 10.1016/S0040-4039(01)85238-2

Check Digit Verification of cas no

The CAS Registry Mumber 670-98-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,7 and 0 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 670-98:
(5*6)+(4*7)+(3*0)+(2*9)+(1*8)=84
84 % 10 = 4
So 670-98-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H8O2S/c1-9-10(8)7-5-3-2-4-6-7/h2-6H,1H3

670-98-4 Well-known Company Product Price

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  • TCI America

  • (M2971)  Methyl Benzenesulfinate  >98.0%(GC)

  • 670-98-4

  • 5g

  • 990.00CNY

  • Detail
  • TCI America

  • (M2971)  Methyl Benzenesulfinate  >98.0%(GC)

  • 670-98-4

  • 25g

  • 2,990.00CNY

  • Detail
  • Aldrich

  • (460893)  Methylbenzenesulfinate  98%

  • 670-98-4

  • 460893-5ML

  • 1,157.13CNY

  • Detail
  • Aldrich

  • (460893)  Methylbenzenesulfinate  98%

  • 670-98-4

  • 460893-25ML

  • 3,707.73CNY

  • Detail

670-98-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl benzenesulfinate

1.2 Other means of identification

Product number -
Other names METHYL BENZENESULFINATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:670-98-4 SDS

670-98-4Relevant articles and documents

Unified Approach to Benzo[ d]thiazol-2-yl-Sulfonamides

Zále?ák, Franti?ek,Ková?, Ond?ej,Lachetová, Eli?ka,?t'astná, Nikola,Pospí?il, Ji?í

supporting information, p. 11291 - 11309 (2021/09/07)

In this paper, we report a unified approach to N-substituted and N,N-disubstituted benzothiazole (BT) sulfonamides. Our approach to BT-sulfonamides starts from simple commercially available building blocks (benzo[d]thiazole-2-thiol and primary and secondary amines) that are connected via (a) a S oxidation/S-N coupling approach, (b) a S-N coupling/S-oxidation sequence, or via (c) a S-oxidation/S-F bond formation/SuFEx approach. The labile N-H bond in N-monoalkylated BT-sulfonamides (pKa (BTSO2N(H)Bn) = 3.34 ± 0.05) further allowed us to develop a simple weak base-promoted N-alkylation method and a stereoselective microwave-promoted Fukuyama-Mitsunobu reaction. N-Alkyl-N-aryl BT-sulfonamides were accessed with the help of the Chan-Lam coupling reaction. Developed methods were further used in stereo and chemoselective transformations of podophyllotoxin and several amino alcohols.

NaHSO3-Mediated Direct Synthesis of Sulfinic Esters from Sulfonyl Hydrazides under Transition-Metal-Free Conditions

Zhang, Guofu,Fan, Qiankun,Wang, Huimin,Zhao, Yiyong,Ding, Chengrong

, p. 833 - 837 (2020/12/07)

We have developed a protocol for the NaHSO3-promoted esterification of sulfonyl hydrazides with alcohols for the synthesis of sulfinic esters. Various sulfonyl hydrazides could be converted to the corresponding sulfinic esters in good to high yields. The merits of this protocol include mild transition-metal-free reaction conditions, an inexpensive and available reagent, and operational simplicity. Controlled experiments reveal that this transformation probably undergoes via a radical pathway. (Figure presented.).

N-Trifluoromethylthiolated Sulfonimidamides and Sulfoximines: Anti-microbial, Anti-mycobacterial, and Cytotoxic Activity

Thota, Niranjan,Makam, Parameshwar,Rajbongshi, Kamal K.,Nagiah, Savania,Abdul, Naeem Sheik,Chuturgoon, Anil A,Kaushik, Amit,Lamichhane, Gyanu,Somboro, Anou M.,Kruger, Hendrik G.,Govender, Thavendran,Naicker, Tricia,Arvidsson, Per I

supporting information, p. 1457 - 1461 (2019/10/11)

Herein we demonstrate the expanded utility of a recently described N-trifluoromethylthiolation protocol to sulfonimidamide containing substances. The novel N-trifluoromethylthio sulfonimidamide derivatives thus obtained were evaluated for antibacterial activity against Mycobacterium tuberculosis (M. tb.) and Mycobacterium abscessus and Gram + Ve (Streptococcus aureus, Bacillus subtilis), and Gram - Ve (Escherichia coli, Pseudomonas aeruginosa) bacteria. Two compounds, 13 and 15 showed high antimycobacterial activity with MIC value of 4-8 μg/mL; i.e. comparable to WHO recommended first line antibiotic for TB infection ethambutol. The same compounds were also found to be cytotoxic in HepG2 cells (compound 13 IC50 = 15 μg/mL; compound 15 IC50 = 65 μg/mL). A structure activity relationship, using matched pair analysis, gave the unexpected conclusion that the trifluoromethylthio moiety was responsible for the cellular and bacterial toxicity. Given the increasing use of the trifluoromethylthio group in contemporary medicinal chemistry, this observation calls for considerations before implementation of the functionality in drug design.

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