930779-79-6

Upstream product

• 3381-73-5 2-bromo-2-(4-chlorophenyl)acetic acid 
• 122151-38-6 (S)-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one 
• 538-75-0 dicyclohexyl-carbodiimide 
• 52574-79-5 α-bromo-p-chlorophenylacetic acid chloride 
• 1878-66-6 4-chlorophenylacetic Acid 
• 25026-34-0 4-chlorophenacetyl chloride 

Downstream Products

• 23953-39-1 (2R)-2-(4-chlorophenyl)-2-[3-(trifluoromethyl)phenoxy]acetic acid 

Relevant academic research and scientific papers

Compositions and methods for the treatment of metabolic syndrome

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of fo

COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME

The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hyperuricemia, gout; dyslipidemia, obesity, urea cycle disorders, hyperglycemia, insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications,.macrovascular complications, lipid disorders, prediabetes., obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, and post prandial hyperglycemia.

PROCESS FOR THE PREPARATION OF (-)-(4-CHLORO-PHENYL)-(3-TRIFLUOROMETHYL-PHENOXY)-ACETIC ACID 2-ACETYLAMINO-ETHYL ESTER

The present invention is directed to a novel process for the preparation of (4-chloro-phenyl)-(3-thfluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester, useful in the treatment of metabolic disorders and further to a process for the preparation of (4-chloro-phenyl)-(3-thfluoromethyl-phenoxy)-acetic acid, a synthesis intermediate.

Process for the stereoselective preparation of (-)-halofenate and derivatives thereof

The present invention provides a compounds the formula (IV): and methods for producing an α-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member selected from the group consisting of: each R2 is a member indepen