930793-79-6Relevant academic research and scientific papers
Synthesis and pharmacology of glutamate receptor ligands: New isothiazole analogues of ibotenic acid
J?rgensen, Charlotte G.,Clausen, Rasmus P.,Hansen, Kasper B.,Br?uner-Osborne, Hans,Nielsen, Birgitte,Bj?rn Metzler,Kehler, Jan,Krogsgaard-Larsen, Povl,Madsen, Ulf
, p. 463 - 471 (2007)
The naturally occurring heterocyclic amino acid ibotenic acid (Ibo) and the synthetic analogue thioibotenic acid (Thio-Ibo) possess interesting but dissimilar pharmacological activity at ionotropic and metabotropic glutamate receptors (iGluRs and mGluRs).
Isothiazolinone compound and corresponding application
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Paragraph 0235-0242, (2019/07/08)
The invention provides an isothiazolinone compound with an IDO inhibitory activity, and a preparing method and pharmaceutical application thereof. The invention particularly relates to a compound shown in a formula I, pharmaceutically acceptable salts thereof, isomers and prodrugs, wherein definitions of all groups are shown in the description. The invention further relates to compound drug preparations, drug compositions and the application of the compound drug preparations and the drug compositions in treating, relieving and/or preventing various relevant diseases caused by immunosuppressionsuch as tumors, virus infection or autoimmune diseases. The isothiazolinone compound has the excellent IDO inhibitory activity.
