930803-84-2

Upstream product

• 930803-80-8 C₃₀H₃₅NO₃SiS₂ 
• 73454-42-9 (E)-2,2,8,12-tetramethyl-5-methylene-7,11-tridecadienal 
• 930803-79-5 C₃₀H₃₅NOSiS₂ 
• 1026920-26-2 C₃₀H₄₂OSi 
• 930803-81-9 C₁₄H₂₄O 
• 930803-83-1 C₁₉H₃₂O₂ 
• 930803-82-0 C₁₄H₂₃I 
• 930803-78-4 (Z)-1-O-tert-butyldiphenylsilyl-3-methylhexa-2-en-1,6-diol 
• 106-25-2 Nerol 
• 139109-04-9 (Z)-1-[(tert-butyldiphenylsilyl)oxy]-3-methyl-2-hexen-6-al 
• 139109-03-8 (Z)-1-[(tert-butyldiphenylsilyl)oxy]-3,7-dimethyl-2,6-octadiene 
• 201670-51-1 (Z)-1-(tert-butyldiphenylsilyloxy)-6,7-epoxy-3,7-dimethylocta-2-ene 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 73454-41-8 (7E)-1-hydroxy-2,2,8,12-tetramethyl-5-methylen-7,11-tridecadiene 

Relevant academic research and scientific papers

Synthesis of moenocinol and its analogs using BT-sulfone in Julia-Kocienski olefination

Moenocinol (C25H42O), the acyclic terpenoid unsaturated lipid part of moenomycin antibiotics, was prepared by an expedient method, which comprised organometallic reaction, Julia-Kocienski olefination, and enolate carbon bond formation as the key steps. The starting materials, nerol and 3-butyn-1-ol, were elaborated to the benzothiazole sulfone 2 and aldehyde 3, and the subsequent Julia-Kocienski olefination occurred in a stereospecific manner to give the desired 6E-configuration of moenocinol. Moenocinol (1) was thus synthesized by 10 linear steps in 12% overall yield, and its analogs 23, 24, and 28 with different chain lengths and unsaturation degrees were also realized by the similar reaction sequences.