930806-53-4

Upstream product

• 111-66-0 oct-1-ene 
• 79271-56-0 triethylsilyl trifluoromethyl sulfonate 
• 123-11-5 4-methoxy-benzaldehyde 
• 1295-35-8 bis(1,5-cyclooctadiene)nickel ⁽⁰⁾ 
• 244187-81-3 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene 

Downstream Products

• 1244955-66-5 C₂₈H₃₃O₄P 
• 1244955-65-4 C₂₈H₃₃O₄P 
• 1244955-99-4 C₂₂H₂₈O₂ 
• 1244956-17-9 C₂₃H₃₀O₂ 

Relevant academic research and scientific papers

Highly selective coupling of alkenes and aldehydes catalyzed by [Ni(NHC){P(OPh)3}]: Synergy between a strong σ donor and a strong π acceptor

(Chemical Equation Presented) Give and take: Both a strong electron donor (1) and a strong electron acceptor (P(OPh)3) are necessary for a highly selective, nickel-catalyzed coupling reaction between alkenes, aldehydes, and silyl triflates (see

TERMINAL 1,1-DISUBSTITUTED ALKENES, METHOD OF MAKING AND USING THEREOF

Disclosed is a process for preparing terminal 1,1-disubstituted alkenes and is to compounds prepared therewith.

Nitrile assisted, Bronsted acid catalyzed regio and stereoselective diarylphosphonylation of allyl silyl ethers

We have discovered a mild, catalytic protocol for the regio- and stereoselective synthesis of trisubstituted allyl diarylphosphonates from the corresponding disubstituted allyl silyl ethers, circumventing the challenges related to the preparation and availability of stereodefined trisubstituted olefins. A closely related arylation reaction was also discovered during the methodology development. By simply switching the reaction medium, high phosphonylation/arylation ratios and vice versa can be achieved. This may not be a direct result of changing solvent polarity. The allyl diarylphosphonates were evaluated as carboxylesterase inhibitors, and the screening results revealed that the inhibitory efficiency is highly related to the choice of alkenes and aryl substituents. The Royal Society of Chemistry 2010.

Nickel-catalyzed coupling of alkenes, aldehydes, and silyl triflates

A full account of two recently developed nickel-catalyzed coupling reactions of alkenes, aldehydes, and silyl triflates is presented. These reactions provide either allylic alcohol or homoallylic alcohol derivatives selectively, depending on the ligand em