93081-15-3

Basic information

• Product Name: O-[(2-Chloro-6-fluorophenyl)methyl]hydroxylamine hydrochloride
• Synonyms: O-[(2-Chloro-6-fluorophenyl)methyl]hydroxylamine hydrochloride;O-(2-Chloro-7-fluorobenzyl)hydroxylaminehydrochloride
• CAS NO: 93081-15-3
• Molecular Formula: C7H8Cl2FNO
• Molecular Weight: 212.0489232
• Mol File: 93081-15-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 184～188℃
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: O-[(2-Chloro-6-fluorophenyl)methyl]hydroxylamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: O-[(2-Chloro-6-fluorophenyl)methyl]hydroxylamine hydrochloride(93081-15-3)
• EPA Substance Registry System: O-[(2-Chloro-6-fluorophenyl)methyl]hydroxylamine hydrochloride(93081-15-3)

Safety Data

• Hazardous Substances Data: 93081-15-3(Hazardous Substances Data)

Usage

General Description

O-[(2-Chloro-6-fluorophenyl)methyl]hydroxylamine hydrochloride, also known as N-(2-Chloro-6-fluorobenzyl)hydroxylamine hydrochloride, is a chemical compound that consists of a hydroxylamine group attached to a benzyl group with a chlorine and fluorine atom substituent. It is commonly used as a reagent in organic chemistry for the preparation of various compounds and as an intermediate in the synthesis of pharmaceuticals and agrochemicals. O-[(2-Chloro-6-fluorophenyl)methyl]hydroxylamine hydrochloride has potential applications in medicinal chemistry, particularly as an anti-tumor agent due to its ability to inhibit tumor growth and induce apoptosis in cancer cells. It is important to handle this compound with care, as it can be hazardous if not used properly.

Downstream Products

• 1003852-48-9 C₂₁H₃₀ClFN₂O₂ 
• 1003852-49-0 C₂₁H₃₀ClFN₂O₂ 

Relevant articles and documents

Synthesis and fungicidal activity of macrolactams and macrolactones with an oxime ether side chain

Three series of novel macrolactams and macrolactones - 12-alkoxyimino- tetradecanlactam, 12-alkoxyiminopentadecanlactam, and 12-alkoxyiminodecanlactone derivatives (7A, 7B, and 7C) - were synthesized from corresponding 12-oxomacrolactams and 12-oxomacrolactone. Their structures were confirmed by 1H NMR and elemental analysis. The Z and E isomers of 7A and 7B were separated, and their configurations were determined by 1H NMR. These compounds showed fair to excellent fungicidal activities against Rhizoctonia solani Kuehn. It is interesting that the Z and E isomers of most of the compounds have quite different fungicidal activities. The fact that the compounds have a gradual increase of fungicidal activity in the order of 7A, 7C, and 7B indicated that the macrocyclic derivatives with a hydrogen-bonding acceptor (=N-O-) and a hydrogen-bonding donor (-CONH-) on the ring, and a three methylenes distance (CH2CH2CH2) between these two functional groups, exhibited the best fungicidal activity. The bioassay also showed that 7B not only has good fungicidal activity but also may have a broad spectrum of fungicidal activities.