93081-15-3

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
O-[(2-Chloro-6-fluorophenyl)methyl]hydroxylamine hydrochloride is used as a reagent for the preparation of various compounds in the pharmaceutical and agrochemical industries, facilitating the synthesis of a range of products.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, O-[(2-Chloro-6-fluorophenyl)methyl]hydroxylamine hydrochloride is used as an intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs.
Used in Antitumor Applications:
O-[(2-Chloro-6-fluorophenyl)methyl]hydroxylamine hydrochloride is used as an anti-tumor agent for its potential to inhibit tumor growth and induce apoptosis in cancer cells, offering a promising avenue for cancer treatment.

Downstream Products

• 1003852-48-9 C₂₁H₃₀ClFN₂O₂ 
• 1003852-49-0 C₂₁H₃₀ClFN₂O₂ 

Relevant academic research and scientific papers

Synthesis and fungicidal activity of macrolactams and macrolactones with an oxime ether side chain

Three series of novel macrolactams and macrolactones - 12-alkoxyimino- tetradecanlactam, 12-alkoxyiminopentadecanlactam, and 12-alkoxyiminodecanlactone derivatives (7A, 7B, and 7C) - were synthesized from corresponding 12-oxomacrolactams and 12-oxomacrolactone. Their structures were confirmed by 1H NMR and elemental analysis. The Z and E isomers of 7A and 7B were separated, and their configurations were determined by 1H NMR. These compounds showed fair to excellent fungicidal activities against Rhizoctonia solani Kuehn. It is interesting that the Z and E isomers of most of the compounds have quite different fungicidal activities. The fact that the compounds have a gradual increase of fungicidal activity in the order of 7A, 7C, and 7B indicated that the macrocyclic derivatives with a hydrogen-bonding acceptor (=N-O-) and a hydrogen-bonding donor (-CONH-) on the ring, and a three methylenes distance (CH2CH2CH2) between these two functional groups, exhibited the best fungicidal activity. The bioassay also showed that 7B not only has good fungicidal activity but also may have a broad spectrum of fungicidal activities.