931112-75-3

Upstream product

• 931112-72-0 6-(5-chloro-2-hydroxy-3-((methylamino)methyl)phenyl)-4-(2-chloro-5-(trifluoromethyl)phenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 931112-50-4 6-(5-chloro-2-hydroxyphenyl)-4-(2-chloro-5-(trifluoromethyl)phenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 
• 931112-51-5 6-(5-chloro-2-hydroxy-3-iodophenyl)-4-(2-chloro-5-(trifluoromethyl)phenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 
• 931112-56-0 6-(5-chloro-3-formyl-2-hydroxyphenyl)-4-(2-chloro-5-(trifluoromethyl)phenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 

Downstream Products

• 931204-35-2 N-(5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)-N-methyl-4-piperidinecarboxamide 

Relevant academic research and scientific papers

Discovery of a novel small molecule binding site of human survivin

Survivin is one of the most tumor-specific genes in the human genome and is an attractive target for cancer therapy. However, small-molecule ligands for survivin have not yet been described. Thus, an interrogation of survivin which could potentially both

Survivin inhibitors

Compounds that inhibit survivin, compositions containing the compounds and methods of treating diseases in which survivin is unregulated or overexpressed are disclosed.