93172-48-6Relevant academic research and scientific papers
Application of the intramolecular ?-amidoalkylation reaction for the synthesis of 3- and 1,3-alkyl(aryl) 2-formyltetrahydroisoquinolines
Venkov,Ivanov
, p. 1707 - 1719 (2007/10/02)
3- and 1,3-alkyl(aryl) 2-formyltetrahydroisoquinolines 6 are obtained by the application of the intramolecular ?-amidoalkylation reaction from 1-alkyl(aryl)-2-arylethylformamides 2 and aldehydes in acidic medium.
Use of the N-formyliminium ion cyclization for the synthesis of 3-aryl-1,2,3,4-tetrahydroisoquinolines
Maryanoff,Rebarchak
, p. 1245 - 1248 (2007/10/02)
Classical cyclization procedures for the synthesis of 3-arylisoquinolines are fraught with complications. Here, we present the application of an N-acyliminium cyclization to such target molecules. N(1,2-diarylethyl)formamides 1, 4a-4d, and 4f were cyclize
