42825-59-2

Usage

Uses

Used in the Illicit Drug Market:
1-(4-methoxyphenyl)-2-phenylethan-1-amine is used as a psychoactive substance for its stimulant effects, which include euphoria, increased energy, and heightened alertness. Its ability to increase dopamine and serotonin levels in the brain makes it a sought-after compound in the illicit drug market, despite its legal and health risks.
Used in Research and Forensic Analysis:
In a controlled and legal context, 1-(4-methoxyphenyl)-2-phenylethan-1-amine may be utilized as a research compound to study the effects of substituted cathinones on the brain and nervous system. Additionally, it can be employed in forensic analysis to identify and understand the prevalence of designer drugs in cases related to substance abuse and criminal investigations.

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 108-88-3 toluene 
• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 64187-51-5 N-trimethylsilyl(4-methoxy)benzaldimine 
• 100-39-0 benzyl bromide 
• 25725-55-7 1-(4-methoxyphenyl)-2-phenylethanone 
• 103-80-0 phenylacetyl chloride 
• 100-66-3 methoxybenzene 

Downstream Products

• 131475-33-7 N-(1-p-methoxyphenyl-2-phenylethyl)amino acetaldehyde diethyl acetal 
• 93172-48-6 N-<1-(4-methoxyphenyl)-2-phenylethyl>formamide 
• 163017-88-7 N-[1-(4-Methoxy-phenyl)-2-phenyl-ethyl]-2,2-diphenyl-acetamide 

Relevant academic research and scientific papers

Alkaline-metal-catalyzed one-pot aminobenzylation of aldehydes with toluenes

A novel and easily accessible MN(SiMe3)2 (M = Li or Na)/Cs2CO3 co-catalyzed benzylation of in situ generated N-(trimethylsilyl) aldimines with toluene derivatives has been successfully developed. The catalyst exhibits high chemoselectivity for deprotonation of toluenes at the benzylic position. The utility of this system is exemplified by the one-pot synthesis of a diverse array of bioactive 1,2-diarylethylamines with excellent efficiency and broad functional group tolerance.

THERAPEUTIC FLUOROETHYL UREAS

Compounds of the formula or a pharmaceutically acceptable salt thereof or a tautomer thereof, wherein A and B are as described herein, are useful for treating conditions afflicting mammals.

Convenient Access to Primary Amines by Employing the Barbier-Type Reaction of N-(Trimethylsilyl)imines Derived from Aromatic and Aliphatic Aldehydes

A new versatile preparation of primary amines via benzylation of aromatic and aliphatic aldimines is described. Sonochemical and traditional methods for generation of the reactive intermediates are compared and contrasted. Competitive reactions were analyzed via free energy relationships to support the proposed alkylative mechanism.

Substituted (1,2-Diarylethyl)amide Acyl-CoA:Cholesterol Acyltransferase Inhibitors: Effect of Polar Groups on in Vitro and in Vivo Activity

Substituted (1,2-diarylethyl)amides have been prepared and evaluated for their ability to inhibit microsomal acyl-CoA:cholesterol acyltransferase activity in vitro and to lower hepatic cholesteryl ester content in vivo in a cholesterol-fed hamster.Simple unsubstituted (diarylethyl)amides were potent inhibitors in vitro but showed poor activity in vivo.Introduction of polar groups at specific locations on the diarylethylamine moiety decreased in vitro activity but increased in vivo activity.Both effects were highly structure dependent, suggesting specific interactions which were mediating activity in each model.Optimization of these opposing effects led to compounds which were potent in both models.

10,5-(Iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives. Potent PCP receptor ligands

IDDC (3, 10,5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene) and a series of substituted derivatives were synthesized and evaluated in vitro for their ability to displace tritiated MK-801 ([3H]-2) from its specific binding site in guinea pig brain homogenate. Substitution at the 3- position of 3 with bromine, chlorine, and fluorine led to increased binding affinity. In contrast, substitution of donor groups at the 3-position gave decreased binding affinities, as did all substitutions at the 7-position and on nitrogen. Where racemic mixtures were resolved, the (+)-optical antipodes were more active than their enantiomers or racemates. The most active ligand found in this study was (+)-13e (IC50 = 15.5 ± 4.5 nM). The affinity of (+)-13e for the PCP receptor makes it among the most potent ligands known. In vitro neuroprotection was demonstrated by 3, (+)-3, and (+)-6 (N-Me-IDDC) against glutamate-induced cell death in rat hippocampal cells.