93232-55-4Relevant academic research and scientific papers
De novo design of nonpeptidic compounds targeting the interactions between interferon-α and its cognate cell surface receptor
Bello, Angelica M.,Bende, Tanushree,Wei, Lianhu,Wang, Xiaoyang,Majchrzak-Kita, Beata,Fish, Eleanor N.,Kotra, Lakshmi P.
, p. 2734 - 2743 (2008/12/22)
Type 1 interferons (IFN) bind specifically to the corresponding receptor, IFNAR. Agonists and antagonists for IFNAR have potential therapeutic value in the treatment of viral infections and systemic lupus erythematosus, respectively. Specific sequences on
Fluorine-free titanocenes and the use thereof
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, (2008/06/13)
Fluorine-free titanocene compounds of the formula I or II STR1 in which both R1 radicals are preferably, independently of one another, cyclopentadienyl?, which is unsubstituted or substituted by alkyl,alkoxy or --Si(R2)3, and both R2 radicals are, in particular, alkyl, STR2 Z is --NR10 --, --0-- or --S--, Y is Cl, Br, I, CN, SCN, --O--CO--CH3, --O--CO--phenyl or --O--SO2 --CH3, n is 1 or 2, m is 0 or 1, where the sum of n and m must be 2, R3, R4 and R5 are in particular, independently of one another, hydrogen, Cl, alkyl, cycloalkyl, adamantyl, phenyl, pyrryl or biphenylyl, where these radicals are unsubstituted or substituted by alkyl, Cl, alkylthio, --NR8 R9, phenyl, phenylthio or C1 -C10 alkoxy, or R3, R4 and R5 are alkenyl, alkoxy, cycloalkoxy, phenoxy, benzyloxy, tetrahydrofurfuryloxy, alkylthio, cycloalkylthio, benzylthio or phenylthio, where R3 and R4 are not simultaneously hydrogen, and if Q is a pyrimidyl radical, at least one radical R3 or R4 is alkoxy, cycloalkoxy, phenoxy, benzyloxy, tetrahydrofurfuryloxy or alkenyloxy, and if Z is --NR10 --, R3 and R4 are Cl Br or I, both radicals R6, independently of one another, are alkyl or alkenyl or both radicals R6 together with the nitrogen atom to which they are bonded, form a morpholino radical, R7 is alkyl, cycloalkyl or phenyl, R8 is phenyl or α-tertiary C4 -C6 alkyl, R9 is, in particular, hydrogen, alkyl, cycloalkyl, phenyl or a STR3 radical, where, in addition, the two R9 radicals in --N(R9)2 are identical or different and, together with the nitrogen atom to which they are bonded, may form a 5- or 6-membered heterocyclic ring which, in addition to the nitrogen atom, may also contain further nitrogen, oxygen or sulfur atoms, R10 is as defined for R9 or additionally, in particular, is phenyl which is unsubstituted or substituted by Cl, C1 -C12 alkyl, C1 -C10 alkoxy, C1 -C8 alkylthio, phenylthio, morpholino or --N(C1 -C4 alkyl)2, X is --O--, --S--, STR4 methylene or ethylene, and A is C1 -C12 alkylene or --X--A--X-- is a direct bond, are suitable as photoinitiators for photopolymerisation of compounds containing ethylenically unsaturated double bonds.
