20461-60-3

Basic information

• Product Name: 2,4-DIETHOXYPYRIMIDINE
• Synonyms: 2,4-DIETHOXYPYRIMIDINE;2,4-Diethoxypyrimidine ,98%
• CAS NO: 20461-60-3
• Molecular Formula: C₈H₁₂N₂O₂
• Molecular Weight: 168.19
• Mol File: 20461-60-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 270.3 °C at 760 mmHg
• Flash Point: 99.1 °C
• Appearance: /
• Density: 1.071 g/cm³
• Vapor Pressure: 0.0114mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-DIETHOXYPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIETHOXYPYRIMIDINE(20461-60-3)
• EPA Substance Registry System: 2,4-DIETHOXYPYRIMIDINE(20461-60-3)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 20461-60-3(Hazardous Substances Data)

Usage

Chemical Properties

Colourless liquid

InChI:InChI=1/C8H12N2O2/c1-3-11-7-5-6-9-8(10-7)12-4-2/h5-6H,3-4H2,1-2H3

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 141-52-6 sodium ethanolate 
• 64-17-5 ethanol 
• 64-67-5 diethyl sulfate 
• 66-22-8 uracil 
• 7647-01-0 hydrogenchloride 
• 93232-55-4 4-chloro-2,6-diethoxypyrimidine 
• 6220-43-5 4-ethoxypyrimidin-2-one 

Downstream Products

• 22390-04-1 1,3-diethyluracil 
• 25902-95-8 4-ethoxy-1-ethyl-2(1H)-pyrimidinone 
• 6220-46-8 1-Methyl-4-ethoxypyrimidine-2-one 
• 6220-43-5 4-ethoxypyrimidin-2-one 
• 25957-58-8 2-ethoxypyrimidin-4-one 
• 101935-53-9 2,4-diethoxy-5-nitro-pyrimidine 
• 66-22-8 uracil 
• 65-46-3 CYTIDINE 
• 103824-48-2 2-<(4-ethoxy-1,2-dihydro-2-oxo-1-pyrimidinyl)methoxy>-1,3-propanediyl dibenzoate 
• 110874-33-4 1-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>-4-ethoxy-2-pyrimidinone 
• 23707-29-1 1-(Tetra-O-acetyl-β-D-glucopyranosyl)-4-ethoxy-2(1H)-pyrimidon 

Relevant articles and documents

Cs2CO3-Promoted C?O Coupling Protocol Enables Solventless (Hetero)aryl Ether Synthesis under Air Atmosphere

In this work, a Cs2CO3-promoted synthetic approach was identified for (hetero)aryl ether synthesis via the C?O coupling of various (hetero)aryl chlorides and alcohols/phenol. To our delight, the reactions could be carried out under transition-metal-free and solvent-free conditions. Moreover, analytical-grade reagents and air atmosphere were readily tolerated. To showcase the practical usefulness of the present protocol, the assembly of a bioactive molecule was facilely realized and the gram-scale production of selected ether products was also efficiently accomplished. In addition, density functional theory (DFT) studies, along with a few mechanistic experiments, were conducted to elucidate a proposed reaction pathway and rationalize the pivotal role of Cs2CO3 in promoting this process. Hopefully, this work could provide useful information for researchers who are engaging in C?O cross-coupling reactions.

Mitsunobu reactions for the synthesis of carbocyclic analogues of nucleosides: Examintion of the regioselectivity

In order to provide a general synthetic method for carbocyclic nucleosides, regioselectivities in Mitsunobu reaction of purine, pyrimidin-2-one and their substituted derivatives with a variety of alcohols with a variety of alcohols were examined and found to depend upon both substituents of the bases and kind of the alcohols.