93272-12-9

Upstream product

• 93271-97-7 1-benzyl 2-methyl (2S)-5-hydroxypyrrolidine-1,2-dicarboxylate 
• 539-44-6 N-4-methylphenylhydrazine 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 147-85-3 L-proline 
• 501-53-1 benzyl chloroformate 
• 5211-23-4 N-carbobenzyloxy-L-proline methyl ester 

Downstream Products

• 93272-14-1 5-methyl-N_b-benzyloxycarbonyl-L-tryptophan 
• 154-06-3 2-Amino-3-(5-methyl-1H-indol-3-yl)-propionic acid 

Relevant academic research and scientific papers

Syntheses of Substituted L- and D-Tryptophans

Several 5-substituted nb-methoxycarbonyl-L- and -D-tryptophan derivatives were synthesized from proline by a new route involving electrochemical oxidation, as well as by the known procedures.Removal of the Nb-methoxycarbonyl group was accomplished by treatment with Me3SiI in refluxing chloroform, then alkaline hydrolysis of the methyl esters afforded 5-substituted L- and D-tryptophans with high optical purities.Keywords - L-tryptophan 5-substituted; D-tryptophan 5-substituted; anodic oxidation; N-methoxycarbonyl group deprotection; Fischer indole synthesis; iodotrimethylsilane