932725-34-3

Upstream product

• 1198161-47-5 C₂₃H₂₅NO₄S 
• 932725-27-4 (S)-N-(2-hydroxy-benzyl)-N-(1-hydroxymethyl-2-phenyl-ethyl)-4-methyl-benzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 51220-86-1 N-(p-toluenesulfonyl)-L-phenylalanine methyl ester 
• 13505-32-3 N-tosyl-(S)-phenylalanine 
• 63-91-2 L-phenylalanine 
• 1303530-22-4 N-(1-benzyl-2-hydroxyethyl)-N-(2-bromobenzyl)-4-methylbenzenesulfonamide 
• 1303530-14-4 2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]-3-phenylpropionic acid methyl ester 

Relevant academic research and scientific papers

A modified synthetic approach to optically pure benzoxazepines from amino acid precursors using intramolecular buchwald-hartwig C-O bond-formation reaction

Palladium-catalyzed intramolecular aryl etherification reaction using bulky binaphthylphosphane ligand is shown to be a convenient method for the synthesis of seven-membered heterocycles. Application of this methodology to a naturally occurring proteinoge

Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: A new class of antithrombotic agents

A diverse group of novel medium ring heterocycles derived from naturally abundant proteinogenic amino acids were evaluated for their potency towards antithrombotic activity. The more potent benzofused oxazepine and oxazocine scaffolds were diversified by incorporating different amino acids at the position number 3. Further the effect of ring size has also been taken into account and it was observed that the eight-membered oxazocines ane more potent compared to the corresponding oxazepines.

Anti-tumor activity of a new series of benzoxazepine derivatives in breast cancer

A series of new benzoxazepine derivatives substituted with different alkoxy and aryloxy group were synthesized comprising synthetic steps of Mitsunobu reaction, lithium aluminum hydride (LAH) reduction, followed by debenzylation and finally intramolecular Mitsunobu cyclization. The new benzoxazepines specifically inhibited growth of breast cancer cell lines, MCF-7 and MDA-MB-231, but lack cytotoxicity to normal HEK-293 cells. The cell growth inhibition induced by the active compounds was due to cell cycle arrest at G0/G1 phase. The active compound could cause significant reduction in tumor volume of MCF-7 xenograft tumor in nude mice model and their activity was comparable to that of tamoxifen citrate at 16 mg kg-1 dose at 30 days of treatment. The identified most active compounds of the series have specific advantages as anti-cancer agent in breast cancer than tamoxifen.

Substituted 1,4-benzoxazepines, 1,5-benzoxazocines, and N- and S-variants

"Chemical Equation Presented" Nucleophilic cleavage of enantiomerically pure 1,2-cyclic sulfamidates with phenol, aniline, and thiophenol nucleophiles, followed by a Mitsunobu reaction, including use of a o-quinomethide variant of this process, provides a