93293-21-1

Usage

General Description

3-(4-Chloro-benzyl)-pyridine is a chemical compound with the molecular formula C12H10ClN. It is a pyridine derivative with a 4-chlorobenzyl group attached to the third position of the pyridine ring. 3-(4-CHLORO-BENZYL)-PYRIDINE is commonly used in the synthesis of various pharmaceuticals and agrochemicals. It has been identified as a potential intermediate in the preparation of antihypertensive agents, antitumor agents, and insecticides. The 4-chlorobenzyl group in 3-(4-Chloro-benzyl)-pyridine is considered to be important for its biological activity and has been utilized in the development of new drug candidates. Additionally, this chemical is also used as a building block in organic synthesis for the preparation of various functionalized pyridine derivatives.

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 29173-25-9 1,4-bis(trimethylsilyl)-1-aza-2,5-cyclohexadiene 
• 110-86-1 pyridine 
• 626-60-8 3-Chloropyridine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 3731-52-0 3-Aminomethylpyridine 

Relevant academic research and scientific papers

Transforming Benzylic Amines into Diarylmethanes: Cross-Couplings of Benzylic Pyridinium Salts via C-N Bond Activation

A nickel-catalyzed cross-coupling of benzylic pyridinium salts with arylboronic acids was developed. Coupled with chemoselective pyridinium formation, this method allows benzyl primary amines to be efficiently converted to di(hetero)arylmethanes. Excellent heteroaryl and functional group tolerance is observed, and a one-pot procedure enables benzylic amines to be converted to diarylmethanes directly.

Reactions of 1,4-Bis(trimethylsilyl)-1,4-dihydropyridines with Carbonyl Compounds: A New Method for Regioselective Synthesis of 3-Alkylpyridines

A new method for the alkyl group introduction at the 3-position of pyridines is described: Reductive disilylation of pyridine, its 2-methyl, 3-methyl, and 4-methyl derivatives affords the corresponding 1,4-disilyl-1,4-dihydropyridines.Tn the presence of a catalytic amount of tetrabutylammonium fluoride, these dihydropyridines smoothly react with a variety of aldehydes and ketones to give 3-alkylpyridines.

REGIOSELECTIVE ALKYL GROUP INTRODUCTION AT THE 3-POSITION OF PYRIDINE VIA 1,4-BIS(TRIMETHYLSILYL)-1,4-DIHYDROPYRIDINE

The reaction of 1,4-bis(trimethylsilyl)-1,4-dihydropyridine with aldehydes and ketones in the presence of tetrabutylammonium fluoride offers a convenient method for the preparation of 3-alkylpyridines.