93299-56-0

Basic information

• Product Name: 2-CHLORO-6,7-DIMETHOXY-3-QUINOLINECARBONITRILE
• Synonyms: 2-CHLORO-6,7-DIMETHOXY-3-QUINOLINECARBONITRILE;2-chloro-6,7-diMethoxyquinoline-3-carbonitrile
• CAS NO: 93299-56-0
• Molecular Formula: C₁₂H₉ClN₂O₂
• Molecular Weight: 248.66506
• Mol File: 93299-56-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 2200.5 °C
• Boiling Point: 414.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -2.60±0.50(Predicted)
• CAS DataBase Reference: 2-CHLORO-6,7-DIMETHOXY-3-QUINOLINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6,7-DIMETHOXY-3-QUINOLINECARBONITRILE(93299-56-0)
• EPA Substance Registry System: 2-CHLORO-6,7-DIMETHOXY-3-QUINOLINECARBONITRILE(93299-56-0)

Safety Data

• Hazardous Substances Data: 93299-56-0(Hazardous Substances Data)

Usage

General Description

2-chloro-6,7-dimethoxy-3-quinolinecarbonitrile is a synthetic chemical compound with a quinoline ring structure and cyano group. It is often used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and other bioactive compounds. 2-chloro-6,7-dimethoxy-3-quinolinecarbonitrile has potential applications in the development of antimalarial, antitumor, and anti-inflammatory drugs due to its unique chemical structure and biological activities. Additionally, it is also utilized in research and development for its potential to target specific biological pathways and receptors. However, it is important to handle and use this compound with caution due to its potential hazardous properties.

Upstream product

• 68236-23-7 2-chloro-6,7-dimethoxy-3-quinolinecarboxaldehyde 
• 881-70-9 3',4'-dimethoxyacetanilide 
• 93299-51-5 2-chloro-6,7-dimethoxy-3-quinolinecarboxaldehyde oxime 
• 209521-75-5 6,7-dimethoxyquinoline-3-carbonitrile 
• 95460-42-7 2-chloro-6,7-dimethoxy-quinoline-3-aldoxime 
• 106-89-8 epichlorohydrin 
• 67-56-1 methanol 

Downstream Products

• 125918-15-2 C₁₉H₁₈N₄O₃S 
• 108198-01-2 N-[(2-Chloro-6,7-dimethoxy-quinolin-3-yl)-diphenyl-methyl]-acetamide 
• 108197-96-2 Phenyl-(2,6,7-trimethoxy-4-phenyl-quinolin-3-yl)-methanone 
• 108197-97-3 2,6,7-Trimethoxy-4-phenyl-quinoline-3-carboxylic acid 
• 108197-99-5 6,7-Dimethoxy-2-methylsulfanyl-4-phenyl-1,4-dihydro-quinoline-3-carbonitrile 
• 108197-86-0 2-Chloro-6,7-dimethoxy-4-phenyl-1,4-dihydro-quinoline-3-carbonitrile 
• 94741-42-1 3-Acetyl-2-chloro-6,7-dimethoxyquinoline 
• 106835-45-4 3-Amino-6,7-dimethoxy-1H-pyrazolo<3,4-b>quinoline 
• 42923-95-5 6,7-Dimethoxy-2-oxo-1,2-dihydro-quinoline-3-carbonitrile 
• 108197-88-2 2-Chloro-6,7-dimethoxy-4-phenyl-quinoline-3-carboxylic acid amide 
• 108197-89-3 C-(2-Chloro-6,7-dimethoxy-quinolin-3-yl)-C,C-diphenyl-methylamine 
• 108197-87-1 (2-Hydroxy-6,7-dimethoxy-4-phenyl-quinolin-3-yl)-phenyl-methanone 
• 94741-44-3 (2-Chloro-6,7-dimethoxy-quinolin-3-yl)-phenyl-methanone 

Relevant articles and documents

lH-Pyrazolo[3,4-b]quinolin-3-amine derivatives inhibit growth of colon cancer cells via apoptosis and sub G1 cell cycle arrest

A series of lH-pyrazolo[3,4-b]quinolin-3-amine derivatives were synthesized and evaluated for anticancer efficacy in a panel of ten cancer cell lines, including breast (MDAMB-231 and MCF-7), colon (HCT-116, HCT-15, HT-29 and LOVO), prostate (DU-145 and PC3), brain (LN-229), ovarian (A2780), and human embryonic kidney (HEK293) cells, a non-cancerous cell line. Among the eight derivatives screened, compound QTZ05 had the most potent and selective antitumor efficacy in the four colon cancer cell lines, with IC50 values ranging from 2.3 to 10.2 μM. Furthermore, QTZ05 inhibited colony formation in HCT-116 cells in a concentration-dependent manner. Cell cycle analysis data indicated that QTZ05 caused an arrest in the sub G1 cell cycle in HCT-116 cells. QTZ05 induced apoptosis in HCT-116 cells in a concentration-dependent manner that was characterized by chromatin condensation and increase in the fluorescence of fluorochrome-conjugated Annexin V. The findings from our study suggest that QTZ05 may be a valuable prototype for the development of chemotherapeutics targeting apoptotic pathways in colorectal cancer cells.

Substituted 1,2,3-triazino[4',5':4,5]-thieno[2,3-B]quinolin-4(3H)-ones

Substituted 1,2,3-triazino[4',5':4,5]thieno[2,3-b]quinolin-4(3H)-ones useful as antiallergic agents are described herein. The compounds are prepared by the reaction of an appropriate substituted 3-aminothieno[2,3-b]quinoline-2-carboxamide with sodium nitrite in an acid such as acetic acid.