933-02-8Relevant articles and documents
FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS
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Page/Page column 115; 116, (2015/07/16)
The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
Chemistry of free cyclic vicinal tricarbonyl compounds ('1,2,3-triones'). Part 1. Reaction of diazomethane and its derivatives with 5,5-dimethylcyclohexane-1,2,3-trione (='oxo-dimedone') and related cyclohexane-1,2,3-triones
Schank, Kurt,La Vecchia, Luigi,Lick, Carlo
, p. 2071 - 2088 (2007/10/03)
Interactions of diazomethane and of its derivatives as typical nucleophiles with cyclic 1,2,3-triones as efficient electrophiles lead to different results: a) formation of oxiranes (C,O insertion under loss of N2), b) nucleophilic addition yiel
A new synthesis of α-β-unsaturated ketones
Le Roux,Le Corre
, p. 2591 - 2594 (2007/10/02)
α,β-unsaturated ketones have been obtained by thermolysis of δ-hydroxy β-keto triphenylphosphoranes prepared from the corresponding β-keto phosphoranes.
