933-02-8

Upstream product

• 2910-65-8 1-cyclopentenylacetyl chloride 
• 18815-73-1 methylzinc iodide 
• 80385-46-2 cyclopent-1-ene-1-carbonyl chloride 
• 71-43-2 benzene 
• 79054-31-2 6,6-Bis-trimethylsilanyl-bicyclo[3.1.0]hexane 
• 75-36-5 acetyl chloride 
• 38134-31-5 1-(1-Hydroxycyclopentyl)propan-2-on 
• 1067-71-6 Diethyl (2-oxopropyl)phosphonate 
• 120-92-3 cyclopentanone 
• 61406-20-0 1-Brom-2-methylen-spiro-<2,4>-heptan 
• 16713-66-9 1,1-cyclopentanediacetic acid 
• 823-91-6 1-cyclopentenylpropan-2-one 
• 141-52-6 sodium ethanolate 
• 4202-14-6 dimethyl (2-oxopropyl)phosphonate 

Downstream Products

• 1122-98-1 1-cyclopentyl-propan-2-one 
• 82683-51-0 spiro[4.5]decane-7,9-dione 

Relevant academic research and scientific papers

FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

METABOTROPIC GLUTAMATE RECEPTOR MODULATORS

The invention relates to heterocyclic derivatives of formula (I) as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are mGluR5 modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders wherein Y, W, R1, R2 and R3 are as defined in claim 1.

Chemistry of free cyclic vicinal tricarbonyl compounds ('1,2,3-triones'). Part 1. Reaction of diazomethane and its derivatives with 5,5-dimethylcyclohexane-1,2,3-trione (='oxo-dimedone') and related cyclohexane-1,2,3-triones

Interactions of diazomethane and of its derivatives as typical nucleophiles with cyclic 1,2,3-triones as efficient electrophiles lead to different results: a) formation of oxiranes (C,O insertion under loss of N2), b) nucleophilic addition yiel

Meerwein-Ponndorf-Verley-type reductive acetylation of carbonyl compounds to acetates by lanthanide complexes in the presence of isopropenyl acetate

Meerwein-Ponndorf-Verley-type reductive acetylation of carbonyl compounds to acetates was successfully carried out in the presence of isopropenyl acetate under the influence of a catalytic amount of Ln(O(i)Pr)3 at room temperature. Various carbonyl compounds were converted into the corresponding acetates in fair to good yields. (C) 2000 Elsevier Science Ltd.

A new synthesis of α-β-unsaturated ketones

α,β-unsaturated ketones have been obtained by thermolysis of δ-hydroxy β-keto triphenylphosphoranes prepared from the corresponding β-keto phosphoranes.

A FACILE, STEREOSELECTIVE PREPARATION OF (Z)-2,4-PENTADIENOATES BY FAVORSKII REARRANGEMENT

Reaction of 1,3,4-tribromo-2-alkanones, efficiently prepared by direct bromination of the parent enone, with methanolic sodium methoxide gives methyl (Z)-2,4-pentadienoates with high (Z) selectivity about the α,β-double bond.

GEM-DISILYLCYCLOPROPANES: PREPARATION ET UTILISATION EN SYNTHESE ORGANIQUE

A simple general route for the conversion of olefins to gem-disilylcyclopropanes, involving the dichlorocyclopropanation of the double bond followed by silylation using the Me3SiCl/Li/THF reagent at 0-10 deg C, is described.Acetylation of bicyclic derivatives thus obtained constitutes an original synthesis of cycloalkylidene ketones by a process more convenient than those previously used, and also provides new acetyl dihydrofurans.