933046-46-9

Basic information

• Product Name: {2-[2-(2-piperazin-1-yl-ethoxy)ethoxy]ethoxy}-carbamic acid 4-nitro-benzyl ester
• Synonyms: {2-[2-(2-piperazin-1-yl-ethoxy)ethoxy]ethoxy}-carbamic acid 4-nitro-benzyl ester
• CAS NO: 933046-46-9
• Molecular Weight: 396.444
• Mol File: 933046-46-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {2-[2-(2-piperazin-1-yl-ethoxy)ethoxy]ethoxy}-carbamic acid 4-nitro-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {2-[2-(2-piperazin-1-yl-ethoxy)ethoxy]ethoxy}-carbamic acid 4-nitro-benzyl ester(933046-46-9)
• EPA Substance Registry System: {2-[2-(2-piperazin-1-yl-ethoxy)ethoxy]ethoxy}-carbamic acid 4-nitro-benzyl ester(933046-46-9)

Safety Data

• Hazardous Substances Data: 933046-46-9(Hazardous Substances Data)

Upstream product

• 86520-52-7 2-[2-(2-azidoethoxy)ethoxy]ethanol 
• 5197-62-6 2-[2-(chloroethoxy)ethoxy]ethanol 
• 6338-55-2 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol 
• 933046-49-2 methanesulfonic acid 2-{2-[2-(4-nitro-benzyloxycarbonylamino)ethoxy]ethoxy}ethyl ester 
• 933046-50-5 4-(2-{2-[2-(4-nitrobenzyloxycarbonylamino)ethoxy]ethoxy}ethyl)-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 933046-91-4 C₂₉H₄₇N₉O₁₁ 
• 933046-94-7 C₃₁H₄₅N₉O₁₁S 

Relevant articles and documents

Synthesis and evaluation of a small library of graftable thrombin inhibitors derived from (l)-arginine

Novel piperazinyl-amide derivatives of N-α-(aryl-sulfonyl)-l-arginine were synthesized as graftable thrombin inhibitors, in the context of biomaterials' design. The possible disturbance of biological activity due to a variable spacer-arm fixed on the N-4 piperazinyl position and the introduction of a trifluoromethyl group as XPS (X-ray Photoelectron Spectroscopy) tag on the sulfonamide moiety were evaluated in vitro against human α-thrombin. All the compounds of the library were found to be active at the micromolar level, as the reference TAME (N-tosyl-l-arginine methyl ester). The blood compatibilization improvement of poly(ethylene terephthalate) (PET) membrane, coated or grafted by wet chemistry treatment with one representative inhibitor of the library, was also evaluated, showing interesting decrease in blood clot formation.