93316-36-0

Upstream product

• 5883-83-0 5-methoxy-2-(4-methoxyphenyl)-1H-indole 
• 68-12-2 N,N-dimethyl-formamide 
• 637-69-4 4-Methoxystyrene 
• 32338-02-6 2-bromo-4-methoxyaniline 
• 104-94-9 4-methoxy-aniline 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 874-90-8 4-methoxybenzonitrile 
• 158611-21-3 1-benzyl-5-methoxy-2-(4-methoxyphenyl)-1H-indole-3-carbaldehyde 

Downstream Products

• 957059-50-6 {[5-methoxy-2-(4-methoxyphenyl)-1H-indol-3-yl]methylene}malononitrile 

Relevant academic research and scientific papers

Pd-tBuONO Cocatalyzed Aerobic Indole Synthesis

A Pd-tBuONO co-catalyzed scalable and practical synthesis of indoles with molecular oxygen as terminal oxidant is developed. Either terminal or internal 2-vinylanilines could be smoothly converted to desired indoles under one general condition. This method has been evaluated in the large scale synthesis of indomethacin and a potential anti-breast cancer drug candidate 1. (Figure presented.).

Preparing method of bazedoxifene derivative

The invention discloses a synthesis method of a bazedoxifene derivative. According to the preparing method of the bazedoxifene derivative, p-anisidine is adopted as a raw material, and through a six-step reaction, the synthesis of the bazedoxifene derivat

Preparation and Application of Solid, Salt-Stabilized Zinc Amide Enolates with Enhanced Air and Moisture Stability

The treatment of various N-morpholino amides with TMPZnCl?LiCl (TMP=2,2,6,6-tetramethylpiperidyl) and Mg(OPiv)2 in THF at 25 °C provides solid zinc enolates with enhanced air and moisture stability (t1/2 in air: 1–3 h) after solvent evaporation. These enolates undergo Pd- and Cu-catalyzed cross-couplings with (hetero)aryl bromides as well as allylic and benzylic halides. The arylated N-morpholino amides were converted into various ketones by LaCl3?2 LiCl mediated acylation with Grignard reagents. The new, solid enolates were used to prepare a potent anti-breast-cancer drug candidate in six steps and 23 % overall yield.

Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization

The aim of this study was the identification of the essential structural elements in the 12-formyl-5,6-dihydroindolo[2,1-a]isoquinoline system required for the inhibition of tubulin polymerization which is understood to be the predominant mode of action o