93322-08-8

Upstream product

• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 64-17-5 ethanol 
• 75-03-6 ethyl iodide 
• 74-96-4 ethyl bromide 

Relevant academic research and scientific papers

Anticancer activity of half-sandwich ru, rh and ir complexes with chrysin derived ligands: Strong effect of the side chain in the ligand and influence of the metal

An important challenge in the field of anticancer chemotherapy is the search for new species to overcome the resistance of standard drugs. An interesting approach is to link bioactive ligands to metal fragments. In this work, we have synthesized a set of

Glycyrrhetinic acid type derivative as well as preparation method and application thereof

The invention relates to a glycyrrhetinic acid type derivative as well as a preparation method and application thereof and belongs to the technical field of organic synthesis. The novel glycyrrhetinicacid type derivative has a molecular formula shown in t

New alkoxy flavone derivatives targeting caspases: Synthesis and antitumor activity evaluation

The antitumor activity of natural flavonoids has been exhaustively reported. Previously it has been demonstrated that prenylation of flavonoids allows the discovery of new compounds with improved antitumor activity through the activation of caspase-7 activity. The synthesis of twenty-five flavonoids (4-28) with one or more alkyl side chains was carried out. The synthetic approach was based on the reaction with alkyl halide in alkaline medium by microwave (MW) irradiation. The in vitro cell growth inhibitory activity of synthesized compounds was investigated in three human tumor cell lines. Among the tested compounds, derivatives 6, 7, 9, 11, 13, 15, 17, and 18 revealed potent growth inhibitory activity (GI50 10 μM), being the growth inhibitory effect of compound 13 related with a pronounced caspase-7 activation on MCF-7 breast cancer cells and yeasts expressing human caspase-7. A quantitative structure-activity relationship (QSAR) model predicted that hydrophilicity, pattern of ring substitution/shape, and presence of partial negative charged atoms were the descriptors implied in the growth inhibitory effect of synthesized compounds. Docking studies on procaspase-7 allowed predicting the binding of compound 13 to the allosteric site of procaspase-7.

6,8-Dibromo- and 6,8-Diiodo-5,7-dihydroxyflavones as New Potent Antibacterial Agents

Thirteen flavones including chrysin, three natural and nine synthesized compounds, were examined for antibacterial activity. 6,8-Dibromo- (11) and 6,8-diiodo-5,7-dihydroxyflavone (12) exhibited the highest activity against all bacteria with MIC 31.2562.5

Synthesis and α-glucosidase inhibitory activity of chrysin, diosmetin, apigenin, and luteolin derivatives

Several derivatives have been synthesized from chrysin, diosmetin, apigenin, and luteolin, which were isolated from diverse natural plants. The α-glucosidase inhibitory activity of these compounds was evaluated. The glucosidase inhibitory activity of all

Synthesis and hypoglycemic effect of chrysin derivatives

A series of 18 chrysin derivatives, prepared by alkylation and condensation, were fully characterized by NMR and other techniques and tested in vivo against the diabetes mellitus. Several modified compounds especially those with propyl, butyl, octyl and tolyl groups were found to have hypoglycemic effect on diabetic mice in spite of the fact that chrysin itself had inhibited insulin release by 40-60%. None of the test animals died at the maximum dose 500mg/kg and did not cause any significant change in general feature, water and food consumption, body weight and organ weight when we examined the acute oral toxicity of those compounds having significant hypoglycemic effect.

Reactions of 4,6-Bis(acetyl)resorcinol with Alkoxycarbonylalkylidene(triphenyl)phosphoranes. Preparation of Coumarin Derivatives

Reaction of compound 1 with ylide 2a affords compounds 3a,3b and coumarins 4a,5a, 5b, 6a in 77percent total yield.Reaction of 1 with ylide 2b affords coumarin 4b.The acetylderivatives obtained, react further with ylides 2a-c to give pyranochromene-2,8-diones 6b-d.