93323-46-7Relevant academic research and scientific papers
I2-Catalyzed Aerobic α,β-Dehydrogenation and Deamination of Tertiary Alkylamines: Highly Selective Synthesis of Polysubstituted Pyrimidines via Hidden Acyclic Enamines
Gao, Qinghe,Wu, Manman,Zhang, Ke,Yang, Ning,Liu, Mengting,Li, Juan,Fang, Lizhen,Bai, Suping,Xu, Yongtao
supporting information, p. 5645 - 5649 (2020/07/24)
A novel and efficient entrance to the pyrimidine skeleton has been presented via the α,β-dehydrogenation and deamination of tertiary alkylamines. This I2-catalyzed dehydrogenative multicomponent procedure utilizes simple aldehydes to trap the hidden enami
Synthesis method of pyrimidine compound containing alkyl and aryl
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Paragraph 0045-0047, (2020/07/15)
The invention discloses a synthesis method of a pyrimidine compound containing alkyl and aryl, and belongs to the technical field of organic synthesis. Key points of the technical scheme of the invention are as follows: the synthesis method of the pyrimidine compound containing alkyl and aryl comprises the following specific steps: dissolving an aldehyde compound, an amidine hydrochloride compoundand a tertiary aliphatic amine compound in a solvent, adding an iodine reagent and an oxidant, and carrying out a reaction process at 110-150 DEG C to prepare the pyrimidine compound containing alkyland aryl as a target product. The synthesis process is simple and efficient, the pyrimidine compound is directly prepared by one step through a one-pot cascade reaction without transition metal catalysis so that resource waste and environmental pollution caused by use of various reagents in multi-step reaction, purification treatment of reaction intermediates in each step and the like are avoided, the synthesis process is convenient to operate, the raw materials are simple, the reaction conditions are mild, the substrate application range is wide, and meanwhile, alkyl substituents are ingeniously introduced by taking the tertiary fatty amine compound as the raw material.
Transition Metal Free Intermolecular Direct Oxidative C-N Bond Formation to Polysubstituted Pyrimidines Using Molecular Oxygen as the Sole Oxidant
Guo, Wei,Li, Chunsheng,Liao, Jianhua,Ji, Fanghua,Liu, Dongqing,Wu, Wanqing,Jiang, Huanfeng
, p. 5538 - 5546 (2016/07/13)
Various polysubstituted pyrimidines are smoothly formed via a base-promoted intermolecular oxidation C-N bond formation of allylic C(sp3)-H and vinylic C(sp2)-H of allyllic compounds with amidines using O2 as the sole oxid
One-pot double Suzuki couplings of dichloropyrimidines
Anderson, Samantha C.,Handy, Scott T.
experimental part, p. 2721 - 2724 (2010/10/19)
An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed, which enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solvent proved critical to the success of this reaction sequence, with alcoholic solvent mixtures affording much greater reactivity and requiring correspondingly lower temperatures than the use of polar aprotic solvents. Georg Thieme Verlag Stuttgart.
