93324-67-5Relevant academic research and scientific papers
Synthesis of trimethylstannyl arylboronate compounds by sandmeyer-type transformations and their applications in chemoselective cross-coupling reactions
Qiu, Di,Wang, Shuai,Tang, Shengbo,Meng, He,Jin, Liang,Mo, Fanyang,Zhang, Yan,Wang, Jianbo
, p. 1979 - 1988 (2014/04/03)
A synthetic method based on Sandmeyer-type reactions to access both tin- and boron-substituted arenes from nitroaniline derivatives is described. This transformation can be applied to the synthesis of a series of functionalized trimethylstannyl arylboronates. In addition, the chemoselective reaction of the Stille and Suzuki-Miyaura cross-coupling reactions is explored, and a series of m- and p-terphenyl derivatives have been synthesized by conducting consecutive one-pot Stille and Suzuki-Miyaura cross-coupling reactions.
Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption
Sanders, John M.,Song, Yongcheng,Chan, Julian M. W.,Zhang, Yonghui,Jennings, Samuel,Kosztowski, Thomas,Odeh, Sarah,Flessner, Ryan,Schwerdtfeger, Christine,Kotsikorou, Evangelia,Meints, Gary A.,Gómez, Aurora Ortiz,González-Pacanowska, Dolores,Raker, Amy M.,Wang, Hong,Van Beek, Ermond R.,Papapoulos, Socrates E.,Morita, Craig T.,Oldfield, Eric
, p. 2957 - 2963 (2007/10/03)
We report the design, synthesis and testing of a series of novel bisphosphonates, pyridinium-1-yl-hydroxy-bisphosphonates, based on the results of comparative molecular similarity indices analysis and pharmacophore modeling studies of farnesyl diphosphate
Self-Assembly of 3-[4′-(Diethylboryl)phenyl]pyridine and 3-[3′-(Diethylboryl)phenyl]pyridine: Synthesis, Structural Features, and Stability in Solution
Wakabayashi, Shigeharu,Sugihara, Yoshikazu,Takakura, Katsuto,Murata, Shigeru,Tomioka, Hideo,Ohnishi, Shiho,Tatsumi, Kazuyuki
, p. 6999 - 7008 (2007/10/03)
The self-assembly of 3-[4′-(diethylboryl)phenyl]pyridine (3) and 3-[3′-(diethylboryl)phenyl]pyridine (4) was investigated by 1H and 11B NMR spectroscopies and vapor pressure osmometry. It can be seen that in solution 3 affords an equilibrium mixture of oligomers including a cyclic trimer as a major component via intermolecular boron-nitrogen coordination bonds, which is supported by temperature-, concentration-, and solvent-dependent behaviors of 3. In contrast, 4 seems to afford a mixture of oligomers including a cyclic dimer in solution. Judging from the low coalescence temperature in variable-temperature NMR in toluene-d8 and easy scrambling with the corresponding 3-[(diethylboryl)pheny]-5-methoxypyridines at ambient temperature, it is concluded that the intermolecular boron-nitrogen coordination bonds made by 3 or 4 are weaker than those formed by 3-(diethylboryl)pyridine (1) or 2-(diethylboryl)-5-methylpyridine (2). Poor thermal stability was supported by electrospray mass spectrometry and structural analyses utilizing a semi-empirical molecular orbital calculation AM1. It is noted that in the assembly of 4 there is a tendency to maintain high tetrahedral character at the boron atom in the complex at the expense of strain energy. Thus, these features of 3 and 4 in solution are in marked contrast to those of 1 and 2.
