933450-16-9Relevant academic research and scientific papers
Synthesis of 1,3,5-tricarbonyl derivatives by condensation of 1,3-bis(silyl enol ethers) with acid chlorides
Rahn, Thomas,Nguyen, Van T. H.,Dang, T. H. Tam,Ahmed, Zafar,Methling, Karen,Lalk, Michael,Fischer, Christine,Spannenberg, Anke,Langer, Peter
, p. 1957 - 1961 (2007)
A variety of 1,3,5-tricarbonyl derivatives were prepared by reaction of 1,3-bis(silyl enol ethers) with acid chlorides under mild conditions. This includes reactions of both aromatic and aliphatic acid chlorides and bis(acid chlorides). The yields vary de
Synthesis and in vitro studies of pyrone derivatives as scavengers of active oxygen species
Weber,Coudert,Duroux,Leal,Couquelet,Madesclaire
, p. 877 - 884 (2007/10/03)
The antioxidant properties of eleven αpyrones and four γ-pyrones were evaluated by means of three different tests: reduction of the stable free radical, 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide anion scavenging assay and lipid peroxidation assay. In the DPPH test, 6-aryl-5,6-dihydro-4-hydroxypyran2-ones (3) and 4-hydroxypyran-2-one (5f) were the most active derivatives with IC50 values ranging from 36.7 to 394 μmol/1. Potent superoxide anion scavenging properties appeared in derivatives possessing phenol moieties. Thus phenolic pyrones 5e and 5f exhibited a note- worthy activity (IC50 = 0.180 and 0.488 mmol/l, respectively) when reference compound, ascorbic acid, demonstrated only 24 % inhibition at a concentration of 1 mg/ml. In addition derivative 5f significantly inhibited the Fe2+/ADP/ascorbate-induced lipid peroxidation of rat liver microsomes with an IC50 value of 0.069 mmol/l. Due to its multiple mechanism of protective action, compound 5f may be useful for the treatment of oxidative tissue injury in human disease.
