933477-82-8Relevant academic research and scientific papers
MUTILIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
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Page/Page column 94, (2010/11/26)
The invention is intended to provide a novel compound which is useful as an antibacterial agent and a manufacturing intermediate thereof and relates to a mutilin derivative represented by the formula (I) which is useful as an antibacterial agent against a multidrug resistant organism, a manufacturing intermediate thereof and the like. In the formula (I), R1 represents an ethyl group or a vinyl group, P1 represent H or a protecting group for a hydroxy group, R2 and R3 represent H or the like, G represents CH2 or the like, A represents -S-, -SO2-, -O- or the like, m represents an integer of 0 to 4, the Q1 ring represents a saturated heterocyclic group, R4 represents H, a lower alkyl group or the like, and W represents a group represented by the formula (W-1) or an amino protection group. In the formula (W-1), X represents a lower alkylene chain, a single bond or the like, Z1 represents CH or the like, Z2, Z3 and Z4 represent N or the like, and Y1 and Y2 represent H, an amino group, a group represented by the formula (Y-1) or the like. In the formula (Y-1), the Q2 ring represents a saturated heterocyclic group, and R9 and R10 represents H, a lower alkyl group or the like. (I) (W-1) (Y-1)
