6976-04-1

Basic information

• Product Name: sodium 4-aminothiophenolate
• CAS NO: 6976-04-1
• Molecular Formula: C₆H₇NS
• Molecular Weight: 147.176
• Mol File: 6976-04-1.mol

Chemical Properties

• CAS DataBase Reference: sodium 4-aminothiophenolate(CAS DataBase Reference)
• NIST Chemistry Reference: sodium 4-aminothiophenolate(6976-04-1)
• EPA Substance Registry System: sodium 4-aminothiophenolate(6976-04-1)

Safety Data

• Hazardous Substances Data: 6976-04-1(Hazardous Substances Data)

Upstream product

• 100-00-5 4-chlorobenzonitrile 
• 722-27-0 bis(4-aminophenyl)disulfide 

Downstream Products

• 110046-24-7 4-(4-Amino-phenylsulfanylmethyl)-benzoic acid 
• 103439-90-3 4-<(4'-Aminophenylthio)methyl>-3-nitrobenzoic acid 
• 3463-02-3 4-(ethylthio)aniline 
• 93352-49-9 4-amino-2'-nitrodiphenyl sulfide 
• 1193-02-8 4-aminotiophenol 
• 103439-98-1 4-<(4'-Aminophenylsulfonyl)methyl>-3-nitrobenzoic acid 
• 110046-31-6 4-(4-Amino-benzenesulfinylmethyl)-benzoic acid 
• 110046-38-3 4-<((4'-Aminophenyl)sulfonyl)methyl>benzoic acid 
• 2976-71-8 benzyl 4-aminophenyl sulfide 
• 100393-14-4 4-aminophenyl benzyl sulfoxide 
• 27375-52-6 acetic acid-[4-(2-hydroxy-ethanesulfonyl)-anilide] 
• 31086-56-3 P-aminobenzene-β-hydroxyethyl sulfone sulfate 
• 19284-82-3 P-aminobenzene-β-hydroxyethyl sulfide 

Relevant articles and documents

Preparation method of p-aminobenzene-beta-hydroxyethylsulfone sulfate

The invention provides a preparation method of p-aminobenzene-beta-hydroxyethylsulfone sulfate. In the preparation method, parachloronitrobenzene is used as a raw material, and is subjected to reaction steps of reduction, condensation, acylation, catalytic oxidation, esterification and the like, and therefore, the p-aminobenzene-beta-hydroxyethylsulfone sulfate which is high in yield and high in quality can be prepared.

The amino-phenyl-β-hydroxyethyl-P-phenylene sulfide preparation method

The invention discloses a p-aminophenyl-beta-hydroxyethyl sulfide preparation method comprising the steps that: (1) under the effect of a catalyst, sodium sulfide, sodium hydrosulfide and nitro chlorobenzene are mixed, such that nucleophilic substitution reaction, and nitro reduction reaction are carried out; and post-treatment is carried out, such that sodium p-aminothiophenol is obtained; (2) sodium p-aminothiophenol is subjected to a reaction with ethylene oxide, such that p-aminophenyl-beta-hydroxyethyl sulfide is obtained. According to the invention, a mixed solution of sodium sulfide and sodium hydrosulfide is used for replacing a polysulfide solution for carrying out the substitution and reduction reactions, such that the nucleophilic reagent SH has high concentration at the beginning, and the substitution reaction can be smoothly carried out, side reaction can be inhibited, and yield can be improved. Ethylene oxide is used for replacing 2-chloroethanol in a condensation reaction with sodium p-aminothiophenol, such that production process is reduced, and production cost is reduced.

PROCESS FOR PREPARATION OF THIOPHENOL DERIVATIVES

Provided is a process for preparing thiophenol derivatives, using aromatic disulfide as a starting material, and inexpensive sodium bisulfite (NaHSO3) as a reducing agent. The process can be carried out on an industrial scale at low production costs, secures advantageous reaction conditions by using a small amount of water- soluble alcohol solvent. Further, the process can maximize the purity of the products by inhibiting reverse oxidation of the final product by the action of sulfur dioxide (SO2) produced during the preparation process, after solvent extraction of the starting materials present as impurities of the thiophenol derivatives.

Synthesis of 4-amino-2′-nitrodiphenyl sulfide

A method of synthesis of 4-amino-2′-nitrodiphenyl sulfide in an yield of up to 85% and a purity of no less that 93% is proposed. The method involves reaction of 4-chloronitrobenzene with sodium sulfide in water and subsequent reaction of the resulting int