933683-64-8Relevant academic research and scientific papers
Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer
Scott, David A.,Aquila, Brian M.,Bebernitz, Geraldine A.,Cook, Donald J.,Dakin, Les A.,Deegan, Tracy L.,Hattersley, Maureen M.,Ioannidis, Stephanos,Lyne, Paul D.,Omer, Charles A.,Ye, Minwei,Zheng, XiaoLan
body text, p. 4794 - 4797 (2009/05/30)
The bisamide class of kinase inhibitors was identified as being active against CSF-1R. The synthesis and SAR of pyridyl and thiazolyl bisamides are reported, along with the pharmacokinetic properties and in vivo activity of selected examples.
CHEMICAL COMPOUNDS
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Page/Page column 56, (2008/06/13)
The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
