933702-55-7

Basic information

• Product Name: 2-Chloropyrimidine-5-carbaldehyde
• Synonyms: 2-Chloropyrimidine-5-carbaldehyde;2-Chloropyrimidine-5-carboxaldehyde;2-Chloropyrimidine-5-carb...;2-ChloropyriMidine-5-carboxyaldehyde
• CAS NO: 933702-55-7
• Molecular Formula: C₅H₃ClN₂O
• Molecular Weight: 142.54
• Product Categories: Building Blocks;Pyrimidine
• Mol File: 933702-55-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 318.2 °C at 760 mmHg
• Flash Point: 146.2 °C
• Appearance: White to yellow/Powder or Crystalline Powder
• Density: 1.432
• Vapor Pressure: 0.000367mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.03±0.22(Predicted)
• CAS DataBase Reference: 2-Chloropyrimidine-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloropyrimidine-5-carbaldehyde(933702-55-7)
• EPA Substance Registry System: 2-Chloropyrimidine-5-carbaldehyde(933702-55-7)

Safety Data

• Hazardous Substances Data: 933702-55-7(Hazardous Substances Data)

Usage

General Description

2-Chloropyrimidine-5-carbaldehyde is a chemical compound with the molecular formula C6H3ClN2O. It is a yellow, crystalline solid that is mainly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is known for its reactivity and versatility, and it is commonly used in the production of various drugs and agricultural products. 2-Chloropyrimidine-5-carbaldehyde is also used as a building block in the pharmaceutical industry, and it serves as a key starting material in the synthesis of a range of important compounds. Due to its diverse applications and significance in chemical synthesis, this compound is of significant interest to researchers and chemists working in the fields of pharmaceuticals and agrochemicals.

InChI:InChI=1/C5H3ClN2O/c6-5-7-1-4(3-9)2-8-5/h1-3H

Upstream product

• 29671-92-9 chloroformamidine hydrochloride 
• 166757-62-6 2-hydroxypyrimidine-5-carbaldehyde 
• 1046816-75-4 2-chloro-5-hydroxymethyl-pyrimidine 
• 131467-06-6 2-chloro-4-vinylpyrimidine 
• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 120747-84-4 2-aminopyrimidine-5-carboxyaldehyde 
• 55551-49-0 2-N,N-Dimethylaminopyrimidine-5-carboxaldehyde 
• 1416365-77-9 2-(4-((1R,2R)-2-(((4-(ethylsulfonyl)-2-fluorobenzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine 
• 1416366-94-3 2-(4-((1R,2R)-2-(((2-fluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl) piperidin-1-yl)-5-(1-methoxyethyl)pyrimidine 
• 1416366-77-2 1-(2-(4-((1R,2R)-2-(((2-fluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)pyrimidin-5-yl)ethanol 
• 1416365-74-6 2-(4-((1R,2R)-2-(((2-fluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)-5-(methoxymethyl)pyrimidine 
• 1416366-76-1 (2-(4-((1R,2R)-2-(((2-fluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)pyrimidin-5-yl)methanol 
• 1416365-05-3 2-(4-((1R,2R)-2-(((2-fluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)pyrimidine-5-carbaldehyde 
• 1354495-76-3 4-(4,4-difluorocyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-2-[1-(5-formylpyrimidin-2-yl)piperidin-4-yl]-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-5,6,7,8-tetrahydroquinoline 

Relevant articles and documents

Self-Replication and Amplification of Enantiomeric Excess of Chiral Multifunctionalized Large Molecules by Asymmetric Autocatalysis

Self-replication of large chiral molecular architectures is one of the great challenges and interests in synthetic, systems, and prebiotic chemistry. Described herein is a new chemical system in which large chiral multifunctionalized molecules possess asymmetric autocatalytic self-replicating and self-improving abilities, that is, improvement of their enantioenrichment in addition to the diastereomeric ratio. The large chiral multifunctionalized molecules catalyze the production of themselves with the same structure, including the chirality of newly formed asymmetric carbon atoms, in the reaction of the corresponding achiral aldehydes and reagent. The chirality of the large multifunctionalized molecules controlled the enantioselectivity of the reaction in a highly selective manner to construct multiple asymmetric stereogenic centers in a single reaction.

2 -Chloro -5-aldehyde pyrimidine and preparation method thereof

The invention discloses 2-chloro-5-aldehyde pyrimidine and a preparation method thereof. The preparation method comprises the following steps: step 1, adding Arnold salt into a solvent to obtain an arnold salt solution, the chemical structural formula of the Arnold salt is as shown in the specification (I); and step 2, adding chloroformamidine hydrochloride and an alkali into the Arnold salt solution to carry out ring-closing reaction so as to obtain the 2-chloro-5-aldehyde pyrimidine.

NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF

The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.