933775-45-2

Upstream product

• 100-46-9 benzylamine 
• 885123-33-1 (R)-3-(4-fluorophenyl)-3-hydroxypropionic acid methyl ester 
• 63131-29-3 methyl 4-fluorobenzoyl acetate 

Downstream Products

• 933775-24-7 (R)-3-benzyl-6-(4-fluorophenyl)[1,2,3]oxathiazinane-2,2-dioxide 
• 933775-46-3 3-benzyl-6-(4-fluoro-phenyl)-[1,2,3]oxathiazinane 2-oxide 
• 933775-29-2 (R)-3-(benzylamino)-1-(4-fluorophenyl)propan-1-ol 

Relevant academic research and scientific papers

Organocatalytic enantioselective decarboxylative aldol reaction of malonic acid half thioesters with aldehydes

Copycat: A highly enantioselective biomimetic aldol reaction of malonic acid half thioesters with a variety of aldehydes affords optically active β-hydroxy thioesters by employing the cinchona-derived sulfonamide organocatalyst 1. The synthetic utility of this protocol was demonstrated by performing formal syntheses of the antidepressants (R)-fluoxetine, (R)-tomoxetine, (-)-paroxetine, and (R)-duloxetine. Copyright

Stereospecific construction of substituted piperidines. Synthesis of (-)-paroxetine and (+)-laccarin

Short and efficient enantioselective syntheses of (-)-paroxetine and (+)-laccarin are described based on the highly stereospecific cleavage of C(3)-substituted 1,3-cyclic sulfamidates. The Royal Society of Chemistry.