933775-46-3

Upstream product

• 885123-33-1 (R)-3-(4-fluorophenyl)-3-hydroxypropionic acid methyl ester 
• 63131-29-3 methyl 4-fluorobenzoyl acetate 
• 933775-45-2 (R)-N-benzyl-3-(4-fluorophenyl)-3-hydroxypropionamide 
• 933775-29-2 (R)-3-(benzylamino)-1-(4-fluorophenyl)propan-1-ol 

Downstream Products

• 933775-24-7 (R)-3-benzyl-6-(4-fluorophenyl)[1,2,3]oxathiazinane-2,2-dioxide 

Relevant academic research and scientific papers

Asymmetric Hydrogenation of β-Secondary Amino Ketones Catalyzed by a Ruthenocenyl Phosphino-oxazoline-ruthenium Complex (RuPHOX-Ru): The Synthesis of γ-Secondary Amino Alcohols

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX-Ru) was applied successfully to the asymmetric hydrogenation of β-secondary amino ketones, directly affording the corresponding chiral γ-secondary amino alcohols in up to 99% yield and with 99% ee. Reaction with β-(benzylamino)-1-phenylpropan-1-one could be performed on a gram-scale with a relatively low catalyst loading (up to 2000 S/C). The resulting hydrogenated product could be used for the synthesis of synthetically useful compounds.

Stereospecific construction of substituted piperidines. Synthesis of (-)-paroxetine and (+)-laccarin

Short and efficient enantioselective syntheses of (-)-paroxetine and (+)-laccarin are described based on the highly stereospecific cleavage of C(3)-substituted 1,3-cyclic sulfamidates. The Royal Society of Chemistry.