93413-86-6

Basic information

• Product Name: 1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol
• Synonyms: 1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol
• CAS NO: 93413-86-6
• Molecular Formula: C₁₆H₂₅NO
• Molecular Weight: 247.3758
• Product Categories: Aromatics, Miscellaneous Reagents
• Mol File: 93413-86-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol(93413-86-6)
• EPA Substance Registry System: 1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol(93413-86-6)

Safety Data

• Hazardous Substances Data: 93413-86-6(Hazardous Substances Data)

Usage

Description

1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol is an organic compound characterized by its unique molecular structure, which features a cyclohexanol ring with a dimethylamino-substituted phenylethyl group attached to the first carbon. 1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol exhibits interesting chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol is used as a key intermediate in the synthesis of ethylamine derivatives for their antidepressant activity. 1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol plays a crucial role in the development of new medications aimed at treating depression and related mood disorders, offering potential benefits in terms of efficacy and safety.

Upstream product

• 93413-62-8 O-desmethylvenlafaxine 
• 108-94-1 cyclohexanone 
• 1126-71-2 N,N-dimethylphenethylamine 
• 18925-69-4 N,N-dimethyl-2-phenylacetamide 
• 103-82-2 phenylacetic acid 

Relevant articles and documents

Electrochemical Activation of Diverse Conventional Photoredox Catalysts Induces Potent Photoreductant Activity**

Herein, we disclose that electrochemical stimulation induces new photocatalytic activity from a range of structurally diverse conventional photocatalysts. These studies uncover a new electron-primed photoredox catalyst capable of promoting the reductive cleavage of strong C(sp2)?N and C(sp2)?O bonds. We illustrate several examples of the synthetic utility of these deeply reducing but otherwise safe and mild catalytic conditions. Finally, we employ electrochemical current measurements to perform a reaction progress kinetic analysis. This technique reveals that the improved activity of this new system is a consequence of an enhanced catalyst stability profile.

2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: Synthesis and antidepressant activity

A series of 2-phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives was examined for the ability to inhibit both rat brain imipramine receptor binding and the synaptosomal uptake of norepinephrine (NE) and serotonin (5-HT). Neurotransmitter uptake inhibition was highest for a subset of 2-phenyl-2-(1-hydroxycyclohexyl)dimethylethylamines in which the aryl ring has a halogen or methoxy substituent at the 3- and/or 4-positions. Potential antidepressant activity in this subset was assayed in three rodent models - the antagonism of reserpine-induced hypothermia, the antagonism of histamine-induced ACTH release, and the ability to reduce noradrenergic responsiveness in the rat pineal gland. An acute effect seen in the rat pineal gland with several analogues, including 1-[1-(3,4-dichlorophenyl)-2-(dimethylamino)ethyl]cyclohexanol (23) and 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol (4), was taken as a possible correlate of a rapid onset of antidepressant activity. Compound 4 (venlafaxine) is presently undergoing clinical evaluation.