934240-45-6

Basic information

• Product Name: (2R,5S)-tert-butyl 2-(4-(2-fluorobenzyloxy)phenyl)-5-carbamoylpyrrolidine-1-carboxylate
• Synonyms: (2R,5S)-tert-butyl 2-(4-(2-fluorobenzyloxy)phenyl)-5-carbamoylpyrrolidine-1-carboxylate;1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-1-pyrrolidinecarboxylate
• CAS NO: 934240-45-6
• Molecular Formula: C₂₃H₂₇FN₂O₄
• Molecular Weight: 414.4698832
• Mol File: 934240-45-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R,5S)-tert-butyl 2-(4-(2-fluorobenzyloxy)phenyl)-5-carbamoylpyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,5S)-tert-butyl 2-(4-(2-fluorobenzyloxy)phenyl)-5-carbamoylpyrrolidine-1-carboxylate(934240-45-6)
• EPA Substance Registry System: (2R,5S)-tert-butyl 2-(4-(2-fluorobenzyloxy)phenyl)-5-carbamoylpyrrolidine-1-carboxylate(934240-45-6)

Safety Data

• Hazardous Substances Data: 934240-45-6(Hazardous Substances Data)

Upstream product

• 446-48-0 o-fluorobenzyl bromide 
• 934240-44-5 tert-butyl (2S,5R)-2-carbamoyl-5-(4-hydroxyphenyl)pyrrolidine-1-carboxylate 
• 934584-88-0 (2S,5R)-1-tert-butyl 2-methyl 5-(4-(2-fluorobenzyl)oxy)phenylpyrrolidine-1,2-dicarboxylate 
• 108963-96-8 (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one 
• 934240-59-2 1-[(4-bromophenoxy)methyl]-2-fluorobenzene 
• 106-41-2 4-bromo-phenol 
• 928-92-7 (E)-hex-4-en-1-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 934240-37-6 (S)-methyl 5-(4-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)-5-oxopentanoate 
• 6793-92-6 p-benzyloxyphenylbromide 
• 77287-34-4 formamide 
• 934584-66-4 1-(tert-butyl) 2-methyl (2S,5R)-5-(4-(benzyloxy)phenyl)pyrrolidine-1,2-dicarboxylate 
• 120186-59-6 (4-(benzyloxy)phenyl)magnesium bromide 

Downstream Products

• 934240-30-9 (2S,5R)-5-(4-((2-fIuorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide 
• 934240-31-0 (2S,5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide monohydrochloride 

Relevant articles and documents

Preparation method of sodium ion channel blocker CNV1014802 hydrochloride form

The invention relates to the field of pharmaceutical chemicals, in particular to a novel preparation method of sodium ion channel blocker (GSK1014802) CNV1014802 hydrochloride for inhibiting sodium ion internal flow, which is a high-selectivity asymmetric

PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYRROLIDINE DERIVATIVES

Disclosed are processes for preparing α-carboxamide pyrrolidine derivatives, in particular (2S,5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and intermediates for use in said processes along with processes for preparing said intermediate

PHARMACEUTICAL COMPOSITIONS COMPRISING 2-METHOXY-5- (5-TRIFLUOROMETHYL-TETRAZOL-I-YL-BENZYL) - (2S-PHENYL-PIPERIDIN-3S-YL-)

The present invention relates to pharmaceutical compositions comprising the NK1 receptor antagonist [2-Methoxy-5-(5-trifuoromethyl-tetrazol-1-yl)-benzyl]-(2S-phenyl- piperidin-3S-yl)-amine, or a pharmaceutically acceptable salt or solvate thereof, and a sodium channel blocker, as a combined preparation for simultaneous or sequential administration and to the use of such compositions in the treatment of certain disorders, including epilepsy, mood disorders and pain.