934339-33-0Relevant academic research and scientific papers
Ex-chiral-pool synthesis of β-hydroxyphosphonate nucleoside analogues
Gallier, Franck,Peyrottes, Suzanne,Perigaud, Christian
, p. 925 - 933 (2008/02/13)
A new series of mononucleotide analogues bearing a nonhydrolysable P-C bond instead of the P-O phosphate linkage is presented. We intend to set up an approach that allows the synthesis of β-hydroxyphosphonate nucleoside analogues as a single diastereoisomer. In this respect, the key "sugar-phosphonate" intermediate was obtained through an Arbusov reaction from an iodosugar derivative in which the stereochemistry of the β-hydroxy group is determined by the choice of the starting material and remains in the resulting nucleotide analogues. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
