29474-73-5

Upstream product

• 591727-19-4 1-2,5-6 di-O-isopropylidene 3-O-benzyl α(D)gluco-pentoaldofuranose 
• 14686-89-6 (1,2:5,6)-di-O-isopropylidene-D-gulose 
• 98-88-4 benzoyl chloride 
• 613-90-1 benzoyl cyanide 
• 2595-05-3 Diacetone D-glucose 
• 2847-00-9 1,2:5,6-di-O-isopropylidene-α-D-hexofuran-3-ulose 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 18819-89-1 tetrabutylammonium benzoate 
• 80667-81-8 1,2:5,6-di-O-isopropylidene-3-O-(N-imidazole-1-sulfonyl)-α-D-glucofuranose 
• 350255-13-9 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 

Downstream Products

• 149402-97-1 Benzoic acid (3aR,5R,6S,6aR)-5-(1,2-dihydroxy-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 
• 31795-13-8 3-O-benzoyl-1,2-O-isopropylidene-α-D-allofuranose 
• 1039343-60-6 3-O-benzoyl-1,2-isopropylidene-α-D-ribo-pentodialdo-1,4-furanose 
• 159043-21-7 3-O-Benzoyl-1,2-O-isopropyliden-6-O-(p-tolylsulfonyl)-α-D-allofuranose 
• 143504-31-8 3-O-Benzoyl-6-deoxy-6-iodo-1,2-O-isopropylidene-α-D-allofuranose 
• 934339-33-0 5-O-acetyl-3-O-benzoyl-6-deoxy-6-iodo-1,2-O-isopropylidene-D-allofuranose 
• 934339-35-2 3-O-benzoyl-6-deoxy-6-diethylphosphono-1,2-O-isopropylidene-D-allofuranose 
• 143504-33-0 3-O-Benzoyl-5-O-benzyloxymethyl-6-deoxy-1,2-O-isopropylidene-α-D-allofuranose 
• 143504-35-2 3-Azido-5-O-benzyloxymethyl-6-deoxy-1,2-O-isopropylidene-α-D-glucofuranose 
• 143504-32-9 3-O-Benzoyl-6-deoxy-1,2-O-isopropylidene-α-D-allofuranose 
• 143504-34-1 5-O-Benzyloxymethyl-6-deoxy-1,2-O-isopropylidene-α-D-allofuranose 
• 80879-44-3 (S)-3-[(4S,5S,6R)-6-(2-Benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-5-methyl-hex-5-enoic acid ethyl ester 
• 80879-44-3 (R)-3-[(4S,5S,6R)-6-(2-Benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-5-methyl-hex-5-enoic acid ethyl ester 
• 80879-43-2 (E)-3-[(4S,5S,6R)-6-(2-Benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-acrylic acid ethyl ester 

Relevant academic research and scientific papers

Glycosyl isoxazole compound, preparation method thereof and bactericide

The invention relates to the technical field of bactericidal materials, and particularly relates to a glycosyl isoxazole compound, a preparation method thereof and a bactericide. The glycosyl isoxazole compound has a structural general formula shown in the description, wherein R1 is selected from any one of substituted or unsubstituted aromatic groups, and R2 is selected from any one of H, acetyl, benzyl and propargyl. According to the invention, a natural saccharide compound is adopted as the framework, the safety is provided, the toxicity is low, the selectivity is high, residue is not easily generated, the environmental compatibility is good, the active group isoxazole structure is further introduced, and the obtained glycosyl isoxazole compound has advantages of safety, high efficiency, low toxicity, low residue, broad spectrum, resistance generation resistance resistance resistance generation resistance and the like, and further has excellent bactericidal activity.

An alternative pathway to ribonucleoside β-hydroxyphosphonate analogues and related prodrugs

Nucleoside β-(S)-hydroxyphosphonate analogues have recently proven to be interesting bioactive compounds as 5′-nucleotidase inhibitors. These derivatives were obtained in a pyrimidine series through an ex-chiral pool pathway or the stereoselective reducti

A facile and practical synthesis of peracylated 4-thio-D-ribofuranoses from D-glucose

(Chemical Equation Presented) A practical synthesis of a peracylated 4-thio-D-ribofuranose 14 starting from inexpensive D-glucose is described. The C2-C6 portion of D-glucose was utilized, in which sulfur was introduced to C5 in two consecutive displacement reactions with net retention of configuration under mild conditions.

Ex-chiral-pool synthesis of β-hydroxyphosphonate nucleoside analogues

A new series of mononucleotide analogues bearing a nonhydrolysable P-C bond instead of the P-O phosphate linkage is presented. We intend to set up an approach that allows the synthesis of β-hydroxyphosphonate nucleoside analogues as a single diastereoisomer. In this respect, the key "sugar-phosphonate" intermediate was obtained through an Arbusov reaction from an iodosugar derivative in which the stereochemistry of the β-hydroxy group is determined by the choice of the starting material and remains in the resulting nucleotide analogues. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Oxidative cleavage of ribofuranose 5-(α-hydroxyphosphonates): a route to erythrofuranose-based nucleoside phosphonic acids

We report here an oxidative cleavage of (5R)- and (5S)-ribofuranosyl-5-C-phosphonate derivatives with periodate anion under both strong acidic and neutral conditions. In both cases, only (5R)-configured compound underwent the expected oxidation reaction a

Nucleoside 5′-C-phosphonates: reactivity of the α-hydroxyphosphonate moiety

We found that various dialkyl phosphites, dialkyl trimethylsilyl phosphites, and tris-trimethylsilyl phosphite reacted smoothly with nucleoside 5′-aldehydes to afford epimeric nucleoside 5′-C-phosphonates in high yields. A number of these compounds in bot

Synthesis and properties of RNA analogues having amides as interuridine linkages at selected positions

Oligoribonucleotide analogues having amide internucleoside linkages (AM1: 3′-CH2CONH-5′ and AM2: 3′-CH 2NHCO-5′) at selected positions have been synthesized and the thermal stability of duplexes formed by these analogues with complem

Homologues of isomeric dideoxynucleosides as potential antiviral agents: Synthesis of isodideoxy-nucleosides with a furanethanol sugar moiety

The synthesis of a homologues series of compounds related to (R, S)- isodideoxynucleosides has been completed by coupling a variety of natural purine and pyrimidine bases with a modified sugar intermediate. This sugar precursor was prepared regiospecifica

An Efficient Synthesis of Enantiomeric Ribonucleic Acids from D-Glucose

Enantiomeric oligoribonucleotides ( = ent-RNA) up to a sequence length of thirty-five and consisting of the (L-configurated) nucleosides ent-adenosine, ent-guanosine, ent-cytidine, ent-uridine, and 1-(β-L-ribofuranosyl)thymine were prepared by automated synthesis from appropriate building blocks, carrying a known photolabile 2′-O-protecting group. A simple large-scale synthesis of the new, prefunctionalized L-ribose derivative 5 from D-glucose (Scheme 1) and its straightforward conversion into the five phosphoramidites 28-32 and five solid supports 38-42, respectively, were elaborated (Scheme 4). Within this project, a novel, superior strategy for the synthesis of the 2′-O-{[(2-nitrobenzyl)oxy]methyl}-substituted key intermediates 18-22 by regioselective alkylation of their 5′-O-dimethoxytritylated precursors 13-17 was developed. Furthermore, an improved set-up for the final light-induced cleavage of the 2′-O-protecting groups from the oligonucleotide sequences was designed (Scheme 5 and Fig. 1). The correct composition of all ent-oligoribonucleotides prepared was established by their MALDI-TOF mass spectra. The 1H-NMR-spectroscopic data of a dodecameric ent-RNA sequence was in excellent agreement with the published data of its natural counterpart, synthesized by conventional methods. The known specific cleavage of a tetradecamer sequence by a 35mer ribozyme structure could be reproduced by ent-oligoribonucleotides, synthesized by the presented methods (Fig. 4).

A precursor to the β-pyranosides of 3-amino-3,6-dideoxy-D-mannose (mycosamine)

S(N)2-type reaction of 3-O-(s1-imidazyl)sulfonyl-1,2:5,6-di-O-isopropylidene-α-D-glucofuran ose with benzoate gave the 3-O-benzoyl-α-D-allo derivative 2, which was hydrolysed to give the 5,6-diol 3. Compound 3 was converted into the 6-deoxy-6-iodo derivat