934355-41-6

Upstream product

• 55116-09-1 2-bromophenylacetyl chloride 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 18698-97-0 ortho-bromophenylacetic acid 

Downstream Products

• 1418222-46-4 1-[(2-bromophenyl)methyl]-3,4-dihydro-6-methoxy-1H-isoquinoline-2-carboxaldehyde 
• 934355-60-9 tert-butyl 1-(2-bromobenzyl)-3,4-dihydro-7-methoxyisoquinoline-2(1H)-carboxylate 
• 934355-49-4 1-[(2-bromophenyl)methyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Identification of Novel 1-O-Substituted Aporphine Analogues as Potent 5-HT2C Receptor Agonists

The 5-HT2C receptor has emerged as a promising target in the treatment of a variety of central nervous system disorders. We have first identified aporphines as a new class of 5-HT2C receptor agonists. Structure-activity relationship

Aporphine alkaloid synthesis and diversification via direct arylation

Palladium-catalyzed direct arylation of aryl chlorides, bromides and iodides has been applied to the preparation of new aporphine analogues including C2-substituted aporphines by reaction with benzodioxole, pyridine N-oxide and pyrazine N-oxide. Successful application of direct arylation in these diversification reactions highlights its utility not only in convergent, but also in divergent synthesis. We also describe enantioselective syntheses of (R)-nornuciferine and (R)-nuciferine employing a catalytic asymmetric transfer hydrogenation in high yield and excellent enantiomeric excess. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.