93447-77-9

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 1071-46-1 hydrogen ethyl malonate 
• 768356-40-7 ethyl (R)-3-amino-3-(2-thienyl)propanoate 
• 18389-46-3 3-amino-3-(thiophen-2-yl)propanoic acid 
• 64-17-5 ethanol 

Downstream Products

• 3270-89-1 (S)-3-amino-3-(2-thienyl)propanoic acid 
• 768356-40-7 ethyl (R)-3-amino-3-(2-thienyl)propanoate 
• 149519-80-2 Ethyl β-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino-]-2-thiophenepropanoate 
• 104883-48-9 3-aminoheptanoic acid 
• 161596-37-8 (S)-β-n-butyl-β-alanine 

Relevant academic research and scientific papers

Dynamic kinetic resolution of β-amino esters by a heterogeneous system of a palladium nanocatalyst and candida antarctica lipase A

A dynamic kinetic resolution (DKR) of β-amino esters have been developed by the use of a heterogeneous racemization catalyst and an immobilized enzyme that accepts aromatic, heteroaromatic and aliphatic substrates. The reaction conditions were optimized to yield an efficient catalytic system without by-product formation. The products are obtained in 96-99 % ee and high yields. Copyright

Burkholderia cepacia lipase is an excellent enzyme for the enantioselective hydrolysis of β-heteroaryl-β-amino esters

The enantioselective (E >200) lipase PS-catalysed hydrolysis of β-heteroaryl-β-amino esters is described. The reactions were performed with H2O (0.5 equiv) in either diisopropyl ether or tert-butyl methyl ether at 25 °C. The resulting β-heteroaryl-substituted β-amino acid enantiomers were formed in high enantiomeric excess (ee ≥ 97%) and in good yield (≥40%).

Candida antarctica lipase A - A powerful catalyst for the resolution of heteroaromatic β-amino esters

Enantioselective acylations of 3-amino-3-heteroarylpropanoates (ArCH(NH2)CH2CO2Et; Ar=2- or 3-thienyl or -furyl) were performed in the presence of Candida antarctica lipase A. As a result of the excellent chemo- and enantioselectivities (E >100), gram-scale resolutions were carried out in ethyl butanoate. The hydrochloride salts of the unreacted R substrates and the butanamides of the reactive S enantiomers were thus prepared.

Substituted heterocyclic derivatives useful as platelet aggregation inhibitors

Novel substituted heterocyclic derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.