93448-51-2Relevant academic research and scientific papers
Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARδ-selective agonists
Fujieda, Hiroki,Usui, Shinya,Suzuki, Takayoshi,Nakagawa, Hidehiko,Ogura, Michitaka,Makishima, Makoto,Miyata, Naoki
, p. 4351 - 4357 (2008/02/12)
To find novel PPARδ-selective agonists, we designed and synthesized phenylpropanoic acid derivatives bearing 6-substituted benzothiazoles. Optimization of this series led to the identification of a potent and selective PPARδ agonist 17. Molecular modeling suggested that compound 17 occupies the Y-shaped pocket of PPARδ appropriately.
Solution-phase parallel synthesis of substituted 1,2-ethyl and 1,3-propyl diamines
Dagan, Ido D.,Lowden, Christopher T.
, p. 7575 - 7577 (2007/10/03)
A solution-phase synthesis for the preparation of substituted 1,2-ethyl and 1,3-propyl diamines has been developed for the purpose of producing diverse lead generation libraries with a minimal scaffold. Crude products were obtained in high purity and further purified through mass guided preparative HPLC.
