934493-79-5

Basic information

• Product Name: 8-Ethyl-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one
• Synonyms: 8-Ethyl-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one
• CAS NO: 934493-79-5
• Molecular Weight: 235.31
• Mol File: 934493-79-5.mol

Chemical Properties

• CAS DataBase Reference: 8-Ethyl-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Ethyl-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one(934493-79-5)
• EPA Substance Registry System: 8-Ethyl-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one(934493-79-5)

Safety Data

• Hazardous Substances Data: 934493-79-5(Hazardous Substances Data)

Upstream product

• 583878-42-6 ethyl 4-chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate 
• 17119-73-2 4-chloro-6-methyl-2-methylthiopyrimidine 
• 6328-58-1 6-methyl-2-methylsulfanyl-3H-pyrimidin-4-one 
• 934493-90-0 4-(ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde 
• 934493-77-3 N-ethyl-5-iodo-6-methyl-2-(methylthio)pyrimidin-4-amine 
• 934493-89-7 [4-(ethylamino)-6-methyl-2-(methylthio)pyrimidin-5-yl]methanol 
• 934493-88-6 ethyl 4-(ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carboxylate 
• 344361-90-6 5-ethoxycarbonyl-6-methyl-2-methylsulfanylpyrimidin-4(3H)-one 

Downstream Products

• 934493-76-2 voxtalisib 

Relevant articles and documents

METHODS OF TREATING CANCER USING PYRIDOPYRIMIDINONE INHIBITORS OF PI3K ALPHA

The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with other cancer treatments. (Formula I)

PYRIDO [2, 3-D] PYRIMIDIN-7-ONE COMPOUNDS AS INHIBITORS OF PI3K-ALPHA FOR THE TREATMENT OF CANCER

The invention is directed to a Compound of Formula I, II, or III. The invention provides compounds that inhibit, regulate, and/or modulate PI3K that are useful in the treatment of hyperproliferatives diseases, such as cancer.

PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα

The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.