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CAS

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934493-76-2

SAR245409, also known as XL765, is a potent and selective dual inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR). This small molecule compound inhibits the catalytic activity of both PI3K and mTOR, which are key regulators of cell growth, proliferation, and survival. Its dual inhibitory activity makes it a promising candidate for combination therapy with other targeted agents or conventional chemotherapies.
Used in Oncology:
SAR245409 is used as an antitumor agent for its promising activity in preclinical studies against a variety of cancers, including breast, lung, and prostate cancer. It modulates the PI3K/mTOR signaling pathway, which plays a crucial role in tumor growth and progression, making it a potential treatment option for cancer patients.
Used in Combination Therapy:
SAR245409 is used as a combination therapy agent with other targeted agents or conventional chemotherapies to enhance the overall therapeutic efficacy and overcome drug resistance in cancer treatment.
Used in Clinical Trials:
SAR245409 is used in ongoing clinical trials to evaluate its efficacy and safety in cancer patients, providing valuable insights into its potential as a novel cancer treatment option.

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  • 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7-one

    Cas No: 934493-76-2

  • USD $ 1.9-2.9 / Gram

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  • 934493-76-2 Structure

  • Basic information

    1. Product Name: SAR245409
    2. Synonyms: Voxtalisib (XL-765);Voxtalisib (XL765, SAR245409);Voxtalisib;2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one;Voxtalisib (SAR245409)
    3. CAS NO:934493-76-2
    4. Molecular Formula: C13H14N6O
    5. Molecular Weight: 270.3
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 934493-76-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 605.0±65.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.397±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 12.54±0.10(Predicted)
    10. CAS DataBase Reference: SAR245409(CAS DataBase Reference)
    11. NIST Chemistry Reference: SAR245409(934493-76-2)
    12. EPA Substance Registry System: SAR245409(934493-76-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 934493-76-2(Hazardous Substances Data)

934493-76-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 934493-76-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,4,4,9 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 934493-76:
(8*9)+(7*3)+(6*4)+(5*4)+(4*9)+(3*3)+(2*7)+(1*6)=202
202 % 10 = 2
So 934493-76-2 is a valid CAS Registry Number.

934493-76-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7-one

1.2 Other means of identification

Product number -
Other names UNII-CVL1685GPH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:934493-76-2 SDS

934493-76-2Downstream Products

934493-76-2Relevant articles and documents

TABLET FORMULATION OF A PI3KALPHA INHIBITOR

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Sheet 1, (2014/09/29)

Provided herein are pharmaceutical formulations comprising a PI3Kα inhibitor, and methods of use thereof for treating cancer in a patient in need of such treatment.

PYRIDO [2, 3-D] PYRIMIDIN-7-ONE COMPOUNDS AS INHIBITORS OF PI3K-ALPHA FOR THE TREATMENT OF CANCER

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Page/Page column 73, (2008/12/08)

The invention is directed to a Compound of Formula I, II, or III. The invention provides compounds that inhibit, regulate, and/or modulate PI3K that are useful in the treatment of hyperproliferatives diseases, such as cancer.

METHODS OF TREATING CANCER USING PYRIDOPYRIMIDINONE INHIBITORS OF PI3K ALPHA

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, (2008/12/04)

The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with other cancer treatments. (Formula I)

PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα

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Page/Page column 65, (2008/06/13)

The invention is directed to Compounds of Formula I and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

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