93451-42-4Relevant academic research and scientific papers
Automated Solution-Phase Synthesis of S-Glycosides for the Production of Oligomannopyranoside Derivatives
Kern, Mallory K.,Pohl, Nicola L. B.
, (2020/06/08)
Thioglycosides are more resistant to enzymatic hydrolysis than their O-linked counterparts, thereby becoming attractive targets for carbohydrate-based therapeutic development. We report the first development of methods for the site-selective incorporation
Chemical Synthesis of d -glycero- d -manno-Heptose 1,7-Bisphosphate and Evaluation of Its Ability to Modulate NF-κB Activation
Inuki, Shinsuke,Aiba, Toshihiko,Kawakami, Shota,Akiyama, Taishin,Inoue, Jun-Ichiro,Fujimoto, Yukari
supporting information, p. 3079 - 3082 (2017/06/23)
D-glycero-d-manno-Heptose 1,7-bisphosphate (HBP) is the precursor for heptose residues found in Gram-negative bacterial membrane surface glycoproteins and glycolipids. HBP β-anomer was recently reported to be a pathogen-associated molecular pattern (PAMP) that regulates TIFA-dependent immunity. Herein, we report the chemical synthesis of HBP α- and β-anomers, which highlights a C-7 carbon homologation via the Corey-Chaykovsky reaction, and the introduction of a phosphate group at the anomeric position using the Mitsunobu reaction. Furthermore, NF-κB reporter assaying revealed that HBP β-anomer activates the NF-κB signaling pathway.
A new approach to construct full-length glycosylphosphatidylinositols of parasitic protozoa and [4-deoxy-Man-III]-GPI analogues
Ali, Asif,Gowda, D. Channe,Vishwakarma, Ram A.
, p. 519 - 521 (2008/09/18)
A new [2 + 2 + 2] approach to construct GPI molecules through the efficient synthesis of glucosamine-inositol and tetramannose intermediates led to a total synthesis of a GPI-anchor of Trypanosoma cruzi, and also afforded a key intermediate for the synthe
Mono- and bivalent ligands bearing mannose 6-phosphate (M6P) surrogates: Targeting the M6P/ insulin-like growth factor II receptor
Berkowitz, David B.,Maiti, Gourhari,Charette, Bradley D.,Dreis, Christine D.,MacDonald, Richard G.
, p. 4921 - 4924 (2007/10/03)
(Chemical Equation Presented) Mannose 6-phosphate mimics locked into the α-configuration and bearing hydrolase-resistant phosphate surrogates were synthesized and evaluated for binding affinity to the mannose 6-phosphate/insulin-like growth factor II rece
Glycosylation using hemiacetal sugar derivatives: Synthesis of O-α-D-rhamnosyl-(1 → 3)-O-α-D-rhamnosyl-(1 → 2) -D-rhamnose and O-α-D-tyvelosyl-(1 → 3)-O-α-D-mannosyl-(1 → 4)-L-rhamnose
Hirooka, Motoko,Yoshimura, Asako,Saito, Izumi,Ikawa, Fumio,Uemoto, Yoko,Koto, Shinkiti,Takabatake, Ayano,Taniguchi, Aya,Shinoda, Yoshika,Morinaga, Aya
, p. 1409 - 1421 (2007/10/03)
O-α-D-Rhamnopyranosyl-(1 → 3)-O-α-D-rhamnopyranosyl-(1 → 2)-D-rhamnopyranose, a repeating trisaccharide of the O-specific polysaccharides (OPSs) of Pseudomonades, and O-α-D-tyvelopyranosyl-(1 → 3)-O-α-D-mannopyranosyl-(1 → 4)-L-rhamnopyranose, a trisaccha
Novel sulforhamnosylacylglycerol derivatives and use thereof as medicaments
-
, (2008/06/13)
Novel sulforhamnosylacylglycerol derivatives represented by General Formula (1): where R101 represents an acyl residue of a higher fatty acid and R102 represents a hydrogen atom or an acyl residue of a higher fatty acid. The derivati
