934558-37-9Relevant academic research and scientific papers
Feedstocks to Pharmacophores: Cu-Catalyzed Oxidative Arylation of Inexpensive Alkylarenes Enabling Direct Access to Diarylalkanes
Vasilopoulos, Aristidis,Zultanski, Susan L.,Stahl, Shannon S.
supporting information, p. 7705 - 7708 (2017/06/20)
A Cu-catalyzed method has been identified for selective oxidative arylation of benzylic C-H bonds with arylboronic esters. The resulting 1,1-diarylalkanes are accessed directly from inexpensive alkylarenes containing primary and secondary benzylic C-H bonds, such as toluene or ethylbenzene. All catalyst components are commercially available at low cost, and the arylboronic esters are either commercially available or easily accessible from the commercially available boronic acids. The potential utility of these methods in medicinal chemistry applications is highlighted.
Noncryogenic preparation of functionalized arylboronic esters through a magnesium-iodine exchange with in situ quench
Demory, Emilien,Blandin, Veronique,Einhorn, Jacques,Chavant, Pierre Y.
scheme or table, p. 710 - 716 (2012/10/23)
Various functionalized aryl boronic esters derived from hexylene glycol and pinacol were prepared in excellent yields according to a simple, safe procedure. The metal-halogen exchange reaction between iPrMgCl? LiCl and aryl iodides is performed
Efficient borylation of reactive aryl halides with MPBH (4,4,6-trimethyl-1,3,2-dioxaborinane)
Praveenganesh, Nageswaran,Demory, Emilien,Gamon, Christine,Blandin, Véronique,Chavant, Pierre Y.
experimental part, p. 2403 - 2406 (2010/11/18)
The combination of 4,4,6-trimethyl-1,3,2-dioxaborinane, a particularly stable and inexpensive borylation reagent, and Buchwalds palladium catalyst provides a simple, fast, cost-effective borylation of electron-rich, reactive iodides, bromides, and triflates to produce stable, easily purified boronic esters. Georg Thieme Verlag Stuttgart New York.
4,4,6-Trimethyl-1,3,2-dioxaborinane: A practical reagent for palladium-catalyzed borylation of aryl halides
Murata, Miki,Oda, Takeshi,Watanabe, Shinji,Masuda, Yuzuru
, p. 351 - 354 (2008/01/06)
The palladium-catalyzed borylation of aryl iodides with 4,4,6-trimethyl-1,3,2-dioxaborinane is described. The mild reaction conditions employed allow for aryl iodides with a wide variety of functional groups to be tolerated. The products of this borylation were coupled with aryl halides to give biaryls in good yields. Georg Thieme Verlag Stuttgart.
