934664-27-4

Basic information

• Product Name: tert-butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate
• Synonyms: tert-butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate
• CAS NO: 934664-27-4
• Molecular Formula: C₂₁H₃₀N₂O₅
• Molecular Weight: 390.4733
• Mol File: 934664-27-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 521.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.243±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.62±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate(934664-27-4)
• EPA Substance Registry System: tert-butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate(934664-27-4)

Safety Data

• Hazardous Substances Data: 934664-27-4(Hazardous Substances Data)

Usage

Description

tert-Butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate is a chemical compound that belongs to the class of azetidines, which are four-membered heterocycles containing one nitrogen atom. It is a derivative of piperidine, a heterocyclic amine, and contains a benzyl ester group and a tert-butyl group. tert-Butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate is significant for medicinal chemistry research and drug development due to its unique structure, which includes a piperidine ring with a hydroxy group, an azetidine ring, and a tert-butyl ester.

Uses

Used in Pharmaceutical Industry:
tert-Butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate is used as a building block in organic synthesis for the preparation of various pharmaceuticals and biologically active molecules. Its unique structure allows it to be a versatile component in the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, tert-Butyl 2-(1-(benzyloxycarbonyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate serves as an important compound for studying the properties and interactions of heterocycles. Its presence in various molecular structures can provide insights into the design and synthesis of potential drug candidates with improved pharmacological properties.

Upstream product

• 388077-74-5 rac-N-(tert-butoxycarbonyl)piperidine-2-carboxamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 75844-69-8 t-butyl piperidinecarboxylate 
• 105258-93-3 N-(Benzyloxycarbonyl)azetidin-3-one 

Downstream Products

• 934665-56-2 (R,S) tert-butyl 2-{1-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl]-3-hydroxy-3-azetidinyl}-1-piperidinecarboxylate 
• 934662-91-6 cobimetinib 
• 1369665-02-0 (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone hemifumarate 
• 934665-56-2 tert-butyl (S)-2-{1-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoyl]-3-hydroxy-3-azetidinyl}perhydropyridine-1-carboxylate 
• 934660-93-2 [14C]-GDC-0973 
• 934666-39-4 1,1-dimethylethyl (2R)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate 
• 934666-39-4 1,1-dimethylethyl (2S)-2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate 
• 934665-54-0 1,1-dimethylethyl (2R)-2-(3-hydroxy-1-{[(phenylmethyl)oxy]carbonyl}azetidin-3-yl)piperidine-1-carboxylate 
• 934665-55-1 1,1-dimethylethyl (2S)-2-(3-hydroxy-1-{[(phenylmethyl)oxy]carbonyl}azetidin-3-yl)piperidine-1-carboxylate 
• 934666-39-4 (R,S) tert-butyl 2-(3-hydroxy-3-azetidinyl)-1-piperidinecarboxylate 
• 934665-53-9 1,1-dimethylethyl (2S)-2-(1-{[(phenylmethyl)oxy]carbonyl}-3-{[(2R)-3,3,3-trifluoro-2-(methyloxy)-2-phenylpropanoyl]oxy}azetidin-3-yl)piperidine-1-carboxylate 
• 934665-52-8 1,1-dimethylethyl (2R)-2-(1-{[(phenylmethyl)oxy]carbonyl}-3-{[(2R)-3,3,3-trifluoro-2-(methyloxy)-2-phenylpropanoyl]oxy}azetidin-3-yl)piperidine-1-carboxylate 

Relevant articles and documents

PROCESS FOR THE PRODUCTION OF COBIMETINIB

The present invention relates to a novel route of synthesis for the production of enantiomerically pure Cobimetinib, new intermediates in the synthesis of Cobimetinib and an amorphous Cobimetinib hemifumarate salt comprising a high salt content.

METHODS OF USING MEK INHIBITORS

The present invention provides methods of treating cancer by administering a compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments.

AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

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