93486-61-4Relevant academic research and scientific papers
New zileuton-hydroxycinnamic acid hybrids: Synthesis and structure-activity relationship towards 5-lipoxygenase inhibition
Chiasson, Audrey Isabel,Robichaud, Samuel,Ndongou Moutombi, Fanta J.,Hébert, Mathieu P.A.,Mbarik, Maroua,Surette, Marc E.,Touaibia, Mohamed
, (2020/10/29)
A novel series of zileuton-hydroxycinnamic acid hybrids were synthesized and screened as 5-lipoxygenase (5-LO) inhibitors in stimulated HEK293 cells and polymorphonuclear leukocytes (PMNL). Zileuton’s (1) benzo[b]thiophene and hydroxyurea subunits combine
Highly Enantioselective Epoxidation of α,β-Unsaturated Ketones Using Amide-Based Cinchona Alkaloids as Hybrid Phase-Transfer Catalysts
Jurczak, Janusz,Majdecki, Maciej,Tyszka-Gumkowska, Agata
supporting information, (2020/11/13)
A series of 20 one chiral epoxides were obtained with excellent yields (up to 99%) and enantioselectivities (up to >99% ee) using hybrid amide-based Cinchona alkaloids. Our method is characterized by low catalyst loading (0.5 mol %) and short reaction times. Moreover, the epoxidation process can be carried out in 10 cycles, without further catalyst addition to the reaction mixture. This methodology significantly enhance the scale of the process using very low catalyst loading.
Substituted benzothiophene or benzofuran derivatives as a novel class of bone morphogenetic protein-2 up-Regulators: Synthesis, structure-activity relationships, and preventive bone loss efficacies in senescence accelerated mice (SAMP6) and ovariectomized
Guo, Hui-Fang,Shao, Hua-Yi,Yang, Zhao-Yong,Xue, Si-Tu,Li, Xue,Liu, Zong-Ying,He, Xiao-Bo,Jiang, Jian-Dong,Zhang, Yue-Qin,Si, Shu-Yi,Li, Zhuo-Rong
experimental part, p. 1819 - 1829 (2010/08/20)
In this work, substituted benzothiophene and benzofuran compounds were found to be a new class of potential anabolic agents by enhancing BMP-2 expression. A series of benzothiophene and benzofuran derivatives have been synthesized, and their activities of
