93496-85-6

Usage

Uses

Methyl 3,3,3-Trifluoro-DL-Lactate is a useful reactant in the preparation of 3-?substituted 5-?(trifluoromethyl)?oxazolidine-?2,?4-?diones via cyclocondensation.

Upstream product

• 67-56-1 methanol 
• 684-07-1 3,3,3-trifluoro-2-hydroxy-propionic acid 
• 13089-11-7 methyl 3,3,3-trifluoropyruvate 
• 920-39-8 isopropylmagnesium bromide 
• 15721-20-7 diisopropyl cadmium 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 1542550-25-3 3-benzyl-5-trifluoromethyloxazolidine-2,4-dione 
• 1446817-41-9 methyl 3,3,3-trifluoro-2-((methyl(phenethyl)carbamoyl)oxy)propanoate 
• 1446817-38-4 1,1,1-trifluoro-3-methoxy-3-oxopropan-2-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

Uncatalyzed Meerwein-Ponndorf-Verley reduction of trifluoromethyl carbonyl compounds by high-temperature secondary alcohols

Noncatalytic Meerwein-Ponndorf-Verley (MPV) reduction of hexafluoroacetone and methyl ester of trifluoropyruvic acid into hexafluoroisopropanol (HFIP) and trifluorolactic esters, respectively can be achieved by heating with secondary alcohols at 210-250 °C without any catalyst.

α-TRIFLUOROMETHYL-α-HYDROXY CARBOXYLIC ACIDS

The methyl esters of α-trifluoromethyl-α-hydroxy carboxylic acids were obtained by the reaction of methyl trifluoropyruvate with organometallic reagents (Cd, Mg, Zn).The characteristic features of the reactions in relation to the nature of the alkylating agent were demonstrated.

REACTION OF HYDROXY AND CARBONYL COMPOUNDS WITH SULFUR TETRAFLUORIDE. XII. REACTIONS OF ESTERS OF ALIPHATIC α- AND β-HYDROXY CARBOXYLIC ACIDS WITH SULFUR TETRAFLUORIDE

The esters of aliphatic and α- and β-hydroxy carboxylic acids react with sulfur tetrafluoride to form the corresponding esters of fluoro carboxylic acids and alkoxycarbonylalkyl fluorosulfites.If electron-withdrawing substituents are introduced at the α position to the carbon atom attached to the hydroxyl group, the reactions of the esters of hydroxy acids with sulfur tetrafluoride take place with substitution of the carbonyl oxygen by two fluorine atoms.

Analogues of clofibrate and clobuzarit containing fluorine in the side chains

A series of analogues of clofibrate and 2-[4-(4-chlorophenyl)phenylmethoxy]-2-methylpropionic acid (clobuzarit) has been prepared by replacing the methyl groups by trifluoromethyl groups and changing the aromatic moiety. The activity of these compounds has been assayed on the plasma levels of cholesterol, Total Esterified Fatty Acids (T.E.F.A.) and fibrinogen in rats. It appears that derivatives of the first series which contain only one trifluoromethyl group are hypocholesterolaemic and that many mono- of bis- trifluoromethyl derivatives of the second series lower the levels of both cholesterol and T.E.F.A. in contrast to clobuzarit.