935-43-3 Usage
General Description
(Phenylcyclopropyl)methylamine Hydrochloride is a chemical compound that belongs to the class of organic compounds known as cyclobutylamines. It is a white crystalline powder that is commonly used in pharmaceutical research and development. The compound has been found to possess various biological activities, including analgesic and anti-inflammatory properties. It is also known to act as a potent inhibitor of the enzyme monoamine oxidase, making it potentially useful in the treatment of certain psychiatric and neurological disorders. Additionally, it has been investigated for its potential role in modulating serotonin and dopamine levels in the brain, which could have implications for the treatment of depression and other mood disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 935-43-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,3 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 935-43:
(5*9)+(4*3)+(3*5)+(2*4)+(1*3)=83
83 % 10 = 3
So 935-43-3 is a valid CAS Registry Number.
935-43-3Relevant articles and documents
Palladium(II)-Catalyzed highly enantioselective C-H arylation of cyclopropylmethylamines
Chan, Kelvin S. L.,Fu, Hai-Yan,Yu, Jin-Quan
, p. 2042 - 2046 (2015)
C-H arylation via a Pd(II)/Pd(IV) catalytic cycle has been one of the most extensively studied C-H activation reactions since the 1990s. Despite the rapid development of this reaction in the past two decades, an enantioselective version has not been reported to date. Herein, we report a Pd(II)-catalyzed highly enantioselective (up to 99.5% ee) arylation of cyclopropyl C-H bonds with aryl iodides using mono-N-protected amino acid (MPAA) ligands, providing a new route for the preparation of chiral cis-aryl-cyclopropylmethylamines. The enantiocontrol is also shown to override the diastereoselectivity of chiral substrates.
