935290-63-4Relevant academic research and scientific papers
Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase
Cheney, I. Wayne,Yan, Shunqi,Appleby, Todd,Walker, Heli,Vo, Todd,Yao, Nanhua,Hamatake, Robert,Hong, Zhi,Wu, Jim Z.
, p. 1679 - 1683 (2007/10/03)
A novel series of highly potent substituted pyridone Pim-1 kinase inhibitors is described. Structural requirements for in vitro activity are outlined as well as a complex crystal structure with the most potent Pim-1 inhibitor reported (IC50 = 5
