491871-58-0 Usage
Uses
TCS PIM-1 1 is a Pim-1 kinase inhibitor.
Biological Activity
tcs pim-1 1 is a selective inhibitor of pim-1 with ic50 value of 50 nm [1].pim-1 is a proto-oncogene serine/threonine-protein kinase and plays an important role in cell cycle progression, apoptosis, transcriptional activation and more general signal transduction pathways. it has been shown that pim-1 over-expression is correlated with a variety of human cancers [2].tcs pim-1 1 is a potent pim-1 inhibitor and has a better selectivity to pim-1 than to pim-2. it was revealed that tcs pim-1 1 was the most potent inhibitor of pim-1 by outlining the crystal structure and it was also shown that tcs pim-1 1 had better inhibitory activity to pim-1 compared with pim-2 [1].
references
[1]. cheney, i.w., et al., identification and structure-activity relationships of substituted pyridones as inhibitors of pim-1 kinase. bioorg med chem lett, 2007. 17(6): p. 1679-83. [2]. cen, b., et al., the pim-1 protein kinase is an important regulator of met receptor tyrosine kinase levels and signaling. mol cell biol, 2014. 34(13): p. 2517-32.
Check Digit Verification of cas no
The CAS Registry Mumber 491871-58-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,1,8,7 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 491871-58:
(8*4)+(7*9)+(6*1)+(5*8)+(4*7)+(3*1)+(2*5)+(1*8)=190
190 % 10 = 0
So 491871-58-0 is a valid CAS Registry Number.
491871-58-0Relevant academic research and scientific papers
Cheney, I. Wayne,Yan, Shunqi,Appleby, Todd,Walker, Heli,Vo, Todd,Yao, Nanhua,Hamatake, Robert,Hong, Zhi,Wu, Jim Z.
, p. 1679 - 1683 (2007)
A novel series of highly potent substituted pyridone Pim-1 kinase inhibitors is described. Structural requirements for in vitro activity are outlined as well as a complex crystal structure with the most potent Pim-1 inhibitor reported (IC50 = 5
