5067-24-3

Basic information

• Product Name: 1-(5-BROMO-2-HYDROXYPHENYL)-3-PHENYL-1,3-PROPANEDIONE
• Synonyms: LABOTEST-BB LT00452365;1-(5-BROMO-2-HYDROXYPHENYL)-3-PHENYL-1,3-PROPANEDIONE;1-(5-BROMO-2-HYDROXYPHENYL)-3-PHENYLPROPANE-1,3-DIONE;1-(5-bromo-2-hydroxyphenyl)-3-phenyl-1,3-propaned;1-(5-BROMO-2-HYDROXYPHENYL)-3-PHENYL-1 &;1-(5-BROMO-2-HYDROXYPHENYL)-3-PHENYL-1,3-PROPANEDIONE 98%;1-(5-Bromo-2-hydroxyphenyl)-3-phenyl-1,3-propanedione,98%
• CAS NO: 5067-24-3
• Molecular Formula: C₁₅H₁₁BrO₃
• Molecular Weight: 319.15
• Product Categories: C15 to C38;Carbonyl Compounds;Ketones
• Mol File: 5067-24-3.mol

Chemical Properties

• Melting Point: 100-103 °C(lit.)
• Boiling Point: 480.5°Cat760mmHg
• Flash Point: 244.4°C
• Appearance: /
• Density: 1.554g/cm³
• Vapor Pressure: 4.81E-10mmHg at 25°C
• Refractive Index: 1.671
• CAS DataBase Reference: 1-(5-BROMO-2-HYDROXYPHENYL)-3-PHENYL-1,3-PROPANEDIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-BROMO-2-HYDROXYPHENYL)-3-PHENYL-1,3-PROPANEDIONE(5067-24-3)
• EPA Substance Registry System: 1-(5-BROMO-2-HYDROXYPHENYL)-3-PHENYL-1,3-PROPANEDIONE(5067-24-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 5067-24-3(Hazardous Substances Data)

Usage

Chemical Properties

yellow crystalline powder

InChI:InChI=1/C15H11BrO3/c16-11-6-7-13(17)12(8-11)15(19)9-14(18)10-4-2-1-3-5-10/h1-9,17-18H/b14-9-

Upstream product

• 4010-28-0 5'-bromo-2'-benzoyloxy-acetophenone 
• 106-41-2 4-bromo-phenol 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 1761-61-1 5-bromosalicyclaldehyde 
• 93-89-0 benzoic acid ethyl ester 
• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 65-85-0 benzoic acid 
• 4079-51-0 1-(3-bromophenyl)-2-hydroxyethan-1-one 
• 98-88-4 benzoyl chloride 
• 75-36-5 acetyl chloride 

Downstream Products

• 935290-63-4 6-(5-bromo-2-hydroxy-phenyl)-2-hydrazino-4-phenyl-nicotinonitrile 
• 935290-58-7 6-(5-bromo-2-hydroxy-phenyl)-2-chloro-4-phenyl-nicotinonitrile 
• 107917-81-7 3,6-dibromo-Flavone 
• 491871-58-0 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile 
• 1218-80-0 6-bromoflavone 

Relevant articles and documents

N-Benzylation of 6-aminoflavone by reductive amination and efficient access to some novel anticancer agents via topoisomerase II inhibition

Series of novel N-benzyl derivatives of 6-aminoflavone (9a–n) were synthesized and evaluated for anticancer and topoisomerase II enzyme inhibition activity. All the synthesized compounds were screened for in vitro anticancer activity against human breast cancer cell line (MCF-7) and human lung cancer cell line (A-549). Among the synthesized compounds, 9f and 9g were found to be the most potent anticancer agents against human breast cancer cell line (MCF-7) with IC50 values of 9.35?μM and 9.58?μM, respectively. Compounds 9b, 9c and 9n exhibited promising anticancer activity against human lung cancer cell line (A-549) with 43.71%, 46.48% and 44.26% inhibition at the highest concentration of 10?μM, respectively. Compounds 9c, 9f and 9g have ability to inhibit the topoisomerase II enzyme. Compound 9f showed most potent topoisomerase II enzyme inhibition activity with IC50 value of 12.11?μM. Further, these compounds have a high potential to be developed as a promising topoisomerase II inhibitors.

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Rh(III)-Catalyzed Aldehydic C?H Functionalization Reaction between Salicylaldehydes and Sulfoxonium Ylides

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An efficient transition-metal-free photoinduced intracyclization of 4H-chromen-4-ones in EtOH-H2O (7:1, v/v) at ambient temperature for the construction of complicated fused-ring heteroaromatics is established. The reaction proceeds smoothly without requiring any catalysts/additives.

Mild and efficient organocatalytic method for the synthesis of flavones

A convenient and efficient organocatalytic procedure for the selective cyclization of 1,3-diketones to give aromatic substituted 4H-chromen-4-ones under mild reaction conditions using N-triflyl phosphoramide is described. Application of the described conditions is presented in a formal synthesis of (S)-flavanone.

Convenient one-pot synthesis of chromone derivatives and their antifungal and antibacterial evaluation

A one-pot method for the synthesis of chromone derivatives from the reaction of 2-hydroxyacetophenones with aliphatic or aromatic acid chlorides is reported. Esterification and Baker-Venkataraman rearrangement were promoted by t-BuOK, which was followed directly by acid-catalyzed cyclization in one pot. Some of 2-cyclohexyl- and 2-cyclohexylmethyl-substituted chromones displayed activity against plant pathogenic fungal strains. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives

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Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor

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