93535-22-9Relevant academic research and scientific papers
Metal-Free Amidation Reactions of Terminal Alkynes with Benzenesulfonamide
Mahato, Sachinta,Santra, Sougata,Zyryanov, Grigory V.,Majee, Adinath
, (2019)
A novel and efficient approach has been developed to synthesize α-sulfonylamino ketones through the reaction between terminal alkynes and sulfonamides under ambient air using PIDA (diacetoxy iodobenzene). A library of α-sulfonylamino ketone derivatives having a variety of substituents has been synthesized. A plausible reaction pathway has been predicted. This reaction offers a broad substrate scope, metal-free synthesis, excellent regioselectivity, easily accessible reactants, and room temperature reaction conditions under ambient air and is operationally simple. A gram-scale synthesis demonstrates the potential applications of the present method. In addition, we have also synthesized α-acetoxy ketones in the case of absence of sulfonamide.
2-Methylquinoline promoted oxidative ring-opening of N-sulfonyl aziridines with DMSO: facile synthesis of α-amino aryl ketones
Zhang, Xianhui,Li, Shuai-Shuai,Wang, Liang,Xu, Lubin,Xiao, Jian,Liu, Zhen-Jiang
, p. 8073 - 8077 (2016/11/19)
2-Methylquinoline promoted room-temperature oxidative ring-opening of N-sulfonyl aziridines with DMSO has been developed, providing a mild and convenient method for the synthesis of a variety of different N-sulfonyl protected α-amino aryl ketones. The employment of 2-methylquinoline was crucial for the success of this mild transformation and good to excellent yields could be achieved.
11-Beta HSD1 inhibitors
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Page/Page column 22, (2008/06/13)
This invention relates to inhibiting 11-beta HSD1.
